Macromolecular engineering of polylactones and polylactides. XXV. Synthesis and characterization of bioerodible amphiphilic networks and their use as controlled drug delivery systems
Macromolecular engineering of polylactones and polylactides. XXV. Synthesis and characterization of bioerodible amphiphilic networks and their use as controlled drug delivery systems
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聚内酯和聚交酯的高分子工程。
DOI：
10.1002/(sici)1099-0518(19990715)37:14
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
R. Jerome
中科院分区：
文献类型：
--
作者：
I. Barakat;P. Dubois;C. Grandfils;R. Jerome
以甲基丙烯酸二乙基铝（Et_2AlO（CH_2）_2OC（O）C（CH_3）CH_2）为引发剂，通过活性开环聚合反应，合成了α，ω-甲基丙烯酰基聚己内酯（PCL）和聚（d，l）-丙交酯P（D，L）LA大分子单体。这些大分子单体与亲水性共聚单体，即，通过使用过氧化苯甲酰作为自由基引发剂，在65°C下本体制备甲基丙烯酸2-羟乙酯。研究了两亲性PHEMA/PCL或P（D，L）LA网络在水和有机介质中的溶胀性能。研究了网络组成和大分子单体分子量对溶胀动力学和平衡溶剂吸收的影响。亲脂性醋酸地塞米松和亲水性磷酸钠对应物已被纳入到两亲性凝胶和他们的释放已被研究的凝胶特性。© 1999 John Wiley & Sons，Inc.聚合物科学杂志A：聚合物化学37：2401-2411，1999
Well-defined α,ω-methacryloyl poly-e-caprolactone (PCL) and poly(d,l)-lactide P(D,L)LA dimacromonomers have been synthesized by living ring-opening polymerization of the parent monomers initiated by diethylaluminum 2-hydroxyethylmethacrylate (Et2AlO(CH2)2OC(O)C(CH3)CH2) and terminated by reaction of the propagating Al alkoxide groups with methacryloyl chloride. These dimacromonomers have been copolymerized with a hydrophilic comonomer, i.e., 2-hydroxyethylmethacrylate, in bulk at 65°C by using benzoyl peroxide as a free-radical initiator. The swelling ability of the amphiphilic PHEMA/PCL or P(D,L)LA networks has been investigated in both aqueous and organic media. Effect of network composition and molecular weight of the dimacromonomer on the swelling kinetics and the equilibrium solvent uptake has been studied. Lipophilic dexamethasone acetate and the hydrophilic sodium phosphate counterpart have been incorporated into the amphiphilic gels and their release has been studied in relation to the gel characteristics. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 2401–2411, 1999