Computer Activities, Physical Exercise, Aging, and Mild Cognitive Impairment: A Population-Based Study
Computer Activities, Physical Exercise, Aging, and Mild Cognitive Impairment: A Population-Based Study
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DOI：
10.1016/j.mayocp.2011.12.020
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发表时间：
2012-05-01
影响因子：
8.9
通讯作者：
Petersen, Ronald C.
中科院分区：
文献类型：
--
作者：
Geda, Yonas E.;Silber, Taryn C.;Petersen, Ronald C.
目的：研究计算机使用、体育锻炼、衰老和轻度认知功能障碍（MCI）之间的关系。患者和方法：马约诊所衰老研究是明尼苏达州奥姆斯特德县一项以人口为基础的衰老和MCI研究。研究样本包括926名年龄在70至93岁之间的非痴呆患者，他们在接受采访后1年内完成了关于体育锻炼、计算机使用和热量摄入的自我报告问卷。本研究于2006年4月1日至2008年11月30日进行。专家共识小组分类每个研究参与者认知正常或有MCI的基础上公布的criteria.Results：使用多变量logistic回归模型，我们研究了存在的影响，在研究期间的2种生活方式的因素（体育锻炼和计算机使用）调整后的第三种生活方式的因素（热量摄入）对衰老和MCI。我们还调整了年龄、性别、教育、医疗合并症和抑郁症。MCI患者的平均每日热量摄入量显著高于对照组（比值比，1.04; 95%置信区间，1.02-1.06; P=.001）。与参考组相比，从事适度体育锻炼和使用计算机的参与者患MCI的几率显著降低（比值比[95%置信区间]，0.36 [0.20-0.68]）。在相互作用分析中，有一个添加剂的相互作用（P= 0.012），但不是乘法的相互作用（P= 0.780）。结论：在这个以人口为基础的样本中，体育锻炼和计算机使用的存在，通过调查评估与MCI的几率降低，调整热量摄入和传统的混杂因素。(C)2012马约医学教育和研究基金会广场马约临床学报2012：87（5）：437-442
Objective: To examine the association between computer use, physical exercise, aging, and mild cognitive impairment (MCI).Patients and Methods: The Mayo Clinic Study of Aging is a population-based study of aging and MCI in Olmsted County, Minnesota. The study sample consists of a random sample of 926 nondemented individuals aged 70 to 93 years who completed self-reported questionnaires on physical exercise, computer use, and caloric intake within 1 year of the date of interview. The study was conducted from April 1, 2006, through November 30, 2008. An expert consensus panel classified each study participant as cognitively normal or having MCI on the basis of published criteria.Results: Using a multivariable logistic regression model, we examined the impact of the presence during the study period of 2 lifestyle factors (physical exercise and computer use) after adjusting for a third lifestyle factor (caloric intake) on aging and MCI. We also adjusted for age, sex, education, medical comorbidity, and depression. The median daily caloric intake was significantly higher in participants with MCI than in controls (odds ratio, 1.04; 95% confidence interval, 1.02-1.06; P=.001). Participants who engaged in both moderate physical exercise and computer use had significantly decreased odds of having MCI (odds ratio [95% confidence interval], 0.36 [0.20-0.68]) compared with the reference group. In the interaction analyses, there was an additive interaction (P=.012) but not multiplicative interaction (P=.780).Conclusion: In this population-based sample, the presence of both physical exercise and computer use as assessed via survey was associated with decreased odds of having MCI, after adjustment for caloric intake and traditional confounders. (C) 2012 Mayo Foundation for Medical Education and Research square Mayo Clin Proc. 2012:87(5):437-442