A digital acoustofluidic device for on-demand and oil-free droplet generation
A digital acoustofluidic device for on-demand and oil-free droplet generation
复制标题
用于按需生成无油液滴的数字声流装置
DOI：
10.1088/1361-6528/aaf3fd
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发表时间：
2019-02-22
期刊：
影响因子：
3.5
通讯作者：
Guo, Feng
中科院分区：
文献类型：
--
作者：
Chen, Keke;Sui, Chenxi;Guo, Feng
我们报告了一个数字声流控装置按需和无油液滴生成。通过将编程的射频信号施加到圆形叉指换能器，产生的动态聚焦声压分布上升并从储器分配样品液体以将液滴动态喷射到空气中。我们的设备可以根据需要分配液滴，精确控制生成时间和顺序，以及精确的液滴体积。此外，我们还证明了在10 ms内产生体积为24 pL的液滴，以及将单个细胞包封到液滴中。这种声流体液滴生成技术简单、生物相容，并且能够精确控制许多不同生物材料的按需液滴生成和封装，这对于单细胞采样和分析应用是有希望的。
We report a digital acoustofluidic device for on-demand and oil-free droplet generation. By applying a programmed radio frequency signal to a circular interdigital transducer, the dynamic focused acoustic pressure profiles generated rise up and dispense sample liquids from a reservoir to dynamically eject the droplets into the air. Our device allows droplets to be dispensed on demand with precisely controlled generation time and sequence, and accurate droplet volume. Moreover, we also demonstrate the generation of a droplet with a volume of 24 pL within 10 ms, as well as the encapsulation of a single cell into droplets. This acoustofluidic droplet generation technique is simple, biocompatible, and enables the on-demand droplet generation and encapsulation of many different biological materials with precise control, which is promising for single cell sampling and analysis applications.