Influence of hypophysectomy, ovariectomy and gonadectomy on postoperative hypersensitivity in rats.
Influence of hypophysectomy, ovariectomy and gonadectomy on postoperative hypersensitivity in rats.
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DOI：
10.15761/gapm.1000145
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Akopian AN
中科院分区：
文献类型：
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作者：
Green DP;Patil MJ;Akopian AN
外科手术会导致脑下垂体持续而深刻的激活，导致内分泌功能的改变。关于脑下垂体的激活是否会影响术后疼痛的阈值和发展时间进程的问题仍然存在。为了解决这些问题，我们分别通过切除垂体腺、卵巢和性腺来评估切除垂体和性腺激素的雌性和雄性大鼠的术后超敏反应。在大鼠的后爪上进行足底切开，建立急性术后疼痛模型。手术切除垂体、卵巢和睾丸，分别切除垂体、卵巢和性腺。术后监测术后7d的温度和机械超敏反应。与正常发情雌、雄大鼠相比，雌性和雄性大鼠去脑垂体术后产生的热和机械过敏阈值和时间进程具有统计学意义上的相似。此外，卵巢切除和性腺切除对对照组雌性和雄性动物的术后超敏反应没有显著影响。我们的实验表明，切除垂体、卵巢和性腺对正常雌性和雄性动物的术后超敏反应没有显著影响。这些数据表明，手术通过激活垂体和随后的性腺组织而引起的内分泌系统的变化对雌性和雄性大鼠术后疼痛的阈值和发展几乎没有影响。
Surgical procedures lead to profound and sustained (up to 1–2 weeks) activation of the pituitary gland, resulting in changes in endocrine function. Questions remain on whether activation of the pituitary influences the threshold and development time-course of postoperative pain. To address these questions, we evaluated postoperative hypersensitivity in female and male rats with ablated pituitary and gonadal hormone productions via hypophysectomy, ovariectomy and gonadectomy, respectively. Plantar incision, a model of acute postoperative pain, or sham operation was performed on rat hind paws. Hypophysectomy, ovariectomy and gonadectomy were achieved by surgical disconnection of pituitary, ovaries and testicles, respectively. Postoperative thermal and mechanical hypersensitivity were monitored for 7 days post incision. Hypophysectomy on female and male rats produced statistically similar thermal and mechanical postoperative hypersensitivity thresholds and time-courses as compared to intact estrous female and male rats. Moreover, ovariectomy and gonadectomy did not significantly change postoperative hypersensitivity observed in control female and male animals. Our experiments demonstrate that hypophysectomy, ovariectomy and gonadectomy do not significantly impact postoperative hypersensitivity observed in normal female and male animals. These data suggest that surgery-induced changes in the endocrine system via activation of pituitary and subsequently gonadal tissues have little impact on the threshold and development of postoperative pain in female and male rats.