Estimating the number of coding mutations in genotypic and phenotypic driven N-ethyl-N-nitrosourea (ENU) screens:: revisited
Estimating the number of coding mutations in genotypic and phenotypic driven N-ethyl-N-nitrosourea (ENU) screens:: revisited
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DOI：
10.1007/s00335-006-0065-z
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发表时间：
2007-02-01
期刊：
影响因子：
2.5
通讯作者：
Valdar, William
中科院分区：
文献类型：
--
作者：
Keays, David A.;Clark, Taane G.;Valdar, William
我们最近描述了在表型和基因型筛选中估计n -乙基-n -亚硝基脲（ENU）诱导的编码突变数量的方法。在本文中，我们重新审视这些方法，阐明它们的应用。我们特别关注无条件概率和条件概率之间的区别。我们还介绍了一个网站来帮助研究者应用这些方程（http://www.well.ox.ac.uk/enuMutRat）。
We recently described methods for estimating the number of N-ethyl-N-nitrosourea (ENU)-induced coding mutations in phenotypic and genotypic screens. In this article we revisit these methods, clarifying their application. In particular, we focus on the difference between unconditional and conditional probabilities. We also introduce a website to assist investigators in the application of these equations (http://www.well.ox.ac.uk/enuMutRat).