Effect of Angiotensin II on Collagen-Induced Platelet Activation in Normotensive Subjects
Effect of Angiotensin II on Collagen-Induced Platelet Activation in Normotensive Subjects
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DOI：
10.1055/s-0038-1645692
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发表时间：
1990-02
影响因子：
6.7
通讯作者：
S. Swartz;T. Moore
中科院分区：
文献类型：
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作者：
S. Swartz;T. Moore
我们观察了血管紧张素II(AII)对15名正常血压志愿者血小板活化的影响。通过在光密度聚集示踪和血栓素生成上测量血小板聚集的初始阶段，我们证明AII增强了胶原诱导的血小板活化。当受试者吃高盐饮食时，这种对血小板活化的促进作用明显大于低盐饮食。此外，血小板活化的增加与血小板AII受体数量的增加是平行的。血小板活化和血小板AII受体的这些平行变化提供了一种可能的机制，通过AII可能影响血小板功能。
Summary We examined the effect of angiotensin II (AII) on platelet activation in 15 normotensive volunteers. By measuring the initial phase of platelet aggregation on the optical density aggregation tracing and generation of thromboxane production, we demonstrated that AII enhances collagen-induced platelet activation. This enhancement in platelet activation is significantly greater when subjects are on a high salt than on a low salt diet. Furthermore, the increase in platelet activation parallels an increase in platelet AII receptor number. These parallel changes in platelet activation and platelet AII receptors provide a possible mechanism through which AII may affect platelet function.