In vitro efficacy of cephamycins against multiple extended-spectrum β-lactamase-producing Klebsiella pneumoniae, Proteus mirabilis, and Enterobacter cloacae isolates from dogs and cats.
In vitro efficacy of cephamycins against multiple extended-spectrum β-lactamase-producing Klebsiella pneumoniae, Proteus mirabilis, and Enterobacter cloacae isolates from dogs and cats.
复制标题
DOI：
10.1292/jvms.23-0052
复制
发表时间：
2023-06-13
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
研究了218株产超广谱β-内酰胺酶（ESBL）肠杆菌科分离株对3种头孢霉素（头孢美唑、氟氧头孢和拉氧头孢）的敏感性。表型检测发现120株肺炎克雷伯菌（KP）和69株阴沟肠杆菌（EC）中分别有8株和15株同时产ESBL和AmpC酶（ABL）。仅产ESBL的KP、奇异变形杆菌和EC对头孢美唑、氟氧头孢和拉氧头孢的敏感率分别为95.5%、82.7%和9.3%、99.1%、96.6%和74.0%、100%和100%。值得注意的是，与仅产ESBL的菌株相比，产ESBL和产ABL的KP和EC菌株对所研究药物的敏感率显著降低。这意味着头霉素对产ESBL细菌的体外活性可能因ABL产量和细菌种类而异。
The susceptibility of 218 extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae isolates from companion animals to three cephamycins (cefmetazole, flomoxef, and latamoxef) was investigated. Phenotypic testing found 8 of 120 Klebsiella pneumoniae (KP) and 15 of 69 Enterobacter cloacae (EC) isolates were ESBL and AmpC β-lactamase (ABL) co-producers. Isolates of KP, Proteus mirabilis, and EC that only produced ESBL exhibited susceptibility rates to cefmetazole (95.5%, 82.7%, and 9.3%), flomoxef (99.1%, 96.6%, and 74.0%), and latamoxef (99.1%, 100%, and 100%), respectively. Notably, isolates of KP and EC co-producing ESBL and ABL had significantly lower susceptibility rates to the studied drugs when compared with only ESBL producers. This implies that the in vitro activity of cephamycins against ESBL-producing bacteria can differ depending on ABL production and bacterial species.
登录
查看更多内容
影响因子：
5.2
作者：
Wang, Cheng-Zhen;Gao, Xun;Liu, Jian-Hua
通讯作者：
Liu, Jian-Hua
DOI：
10.1016/j.ijantimicag.2015.07.020
发表时间：
2015-12-01
影响因子：
10.8
作者：
Lee, Chen-Hsiang;Su, Lin-Hui;Liu, Jien-Wei
通讯作者：
Liu, Jien-Wei
影响因子：
3
作者：
Shimizu, Takae;Harada, Kazuki;Hikasa, Yoshiaki
通讯作者：
Hikasa, Yoshiaki
影响因子：
3.9
作者：
Huang, Chen;Shi, Qingyi;Xiao, Yonghong
通讯作者：
Xiao, Yonghong
影响因子：
6.1
作者：
Perez F;Van Duin D
通讯作者：
Van Duin D