Increased levels of serotonin2A receptors and serotonin transporter in the CNS of neuregulin 1 hypomorphic/mutant mice
Increased levels of serotonin2A receptors and serotonin transporter in the CNS of neuregulin 1 hypomorphic/mutant mice
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DOI：
10.1016/j.schres.2007.10.013
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发表时间：
2008-02-01
影响因子：
4.5
通讯作者：
Scarr, Elizabeth
中科院分区：
文献类型：
--
作者：
Dean, Brian;Karl, Tim;Scarr, Elizabeth
神经调节蛋白1表达的变化已在精神分裂症受试者的CNS中报道。由于神经调节蛋白I在皮质发育中是重要的，我们假设神经调节蛋白I表达的变化可能有助于胆碱能、胆碱能和胆碱能标记物的变化，这些标记物在患有该疾病的受试者的CNS中有充分的记录。为了开始检验这一假设，我们使用原位放射性配体结合来测量杂合跨膜结构域神经调节蛋白I突变小鼠CNS中毒蕈碱M1/M4受体、红藻氨酸受体、NMDA受体、5-羟色胺2A受体、5-羟色胺IA受体和5-羟色胺转运蛋白的水平。这些研究的主要结果是证明血清素2A受体水平的总体增加（F= 11.3，d.f.= 11.3）。3，1，72，p=0.0012）和5-羟色胺转运蛋白（F=5.00，d. f. = 1，3，72，p
Changes in neuregulin 1 expression have been reported in the CNS from subjects with schizophrenia. As neuregulin I is important in cortical development we postulated that changes in neuregulin I expression may contribute towards changes in cholinergic, glutamatergic and serotonergic markers that are well documented in the CNS of subjects with that disorder. To begin to test this hypothesis, we used in situ radioligand binding to measure levels of muscarinic M1/M4 receptors, the kainate receptor, the NMDA receptor, the serotonin 2A receptor, the serotonin I A receptor and the serotonin transporter in the CNS from heterozygous transmembrane domain neuregulin I mutant mice. The major outcomes from these studies was the demonstration of an overall increase in levels of the serotonin 2A receptor (F= 11.3, d.f.=3,1,72, p=0.0012) and serotonin transporter (F=5.00, d.f. = 1,3,72, p