Synergistic Association of House Endotoxin Exposure and Ambient Air Pollution with Asthma Outcomes
Synergistic Association of House Endotoxin Exposure and Ambient Air Pollution with Asthma Outcomes
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DOI：
10.1164/rccm.201809-1733oc
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发表时间：
2019-09-15
影响因子：
24.7
通讯作者：
Thorne, Peter S.
中科院分区：
文献类型：
--
作者：
Mendy, Angelico;Wilkerson, Jesse;Thorne, Peter S.
理论基础：房屋内毒素和环境空气污染是哮喘的危险因素；然而，它们共同暴露对哮喘的影响还没有得到很好的描述。目的：检验房屋粉尘内毒素和环境空气污染物共同暴露与哮喘结局的潜在协同关系。方法：我们分析了2005-2006年国家健康和营养检查调查6488名参与者的数据。对床上用品和卧室地板上的粉尘进行内毒素含量分析。使用社区多尺度空气质量模拟系统(CMAQ)和降标模式数据来确定年平均颗粒物
Rationale: House endotoxin and ambient air pollution are risk factors for asthma; however, the effects of their coexposure on asthma are not well characterized.Objectives: To examine potential synergistic associations of coexposure to house dust endotoxin and ambient air pollutants with asthma outcomes.Methods: We analyzed data of 6,488 participants in the National Health and Nutrition Examination Survey 2005-2006. Dust from bedding and bedroom floor was analyzed for endotoxin content. The Community Multiscale Air Quality Modeling System (CMAQ) and Downscaler Model data were used to determine annual average particulate matter