THE USE OF CONSTANT ROUTINES IN UNMASKING THE ENDOGENOUS COMPONENT OF HUMAN CIRCADIAN RHYTHMS
THE USE OF CONSTANT ROUTINES IN UNMASKING THE ENDOGENOUS COMPONENT OF HUMAN CIRCADIAN RHYTHMS
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DOI：
10.3109/07420528409063897
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发表时间：
1984-01-01
影响因子：
2.8
通讯作者：
WATERHOUSE J M
中科院分区：
文献类型：
--
作者：
MINORS D S;WATERHOUSE J M
研究驱动人类昼夜节律的内部时钟的一个主要问题是由于习惯的节律性和外部影响（掩蔽）产生的影响。在这方面，一个特别有效的因素是睡眠-觉醒周期。反常的是，尽管这种掩蔽影响被广泛接受，但大多数昼夜节律研究都是在存在此类干扰的情况下进行的。描述了一种协议，即可以最小化这些外源影响的恒定例程，从而能够对内部时钟进行更仔细的审查。给出了使用恒定例程的不同情况以及从此类研究中得出的结果。简而言之，他们表明夜间研究可能会提供有关内部时钟对各种操作（例如时区转换、轮班工作）的调整率的误导性信息。描述了利用恒定例程的未来研究，特别是那些可能允许建立多于 1 个内部时钟的存在的研究。
A major problem in the study of the internal clock(s) that drive human circadian rhythms is due to the effect produced by rhythmicity of habits and external influences (masking). A particularly potent factor in this respect is the sleep-wake cycle. It is anomalous that, even though this masking influence is widely accepted, most studies of circadian rhythmicity have been performed in the presence of such interferences. A protocol is described, the constant routine by which these exogenous influences can be minimized, thereby enabling a closer scrutiny of the internal clock(s) to be made. An account is given of the different circumstances in which the constant routines have been used together with the results derived from such studies. Briefly, they indicate that nycthemeral studies can give misleading information about the rate of adjustment of the internal clock to various manipulations, e.g., time-zone transition, shift work. Future studies making use of constant routines are described, in particular those which might enable the presence of more than 1 internal clock to be established.