Relationship between triclosan and susceptibilities of bacteria isolated from hands in the community
Relationship between triclosan and susceptibilities of bacteria isolated from hands in the community
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DOI：
10.1128/aac.48.8.2973-2979.2004
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发表时间：
2004-08-01
影响因子：
4.9
通讯作者：
Larson, E
中科院分区：
文献类型：
--
作者：
Aiello, AE;Marshall, B;Larson, E
三氯生和细菌对抗生素的敏感性之间的可能的关联进行了检查，葡萄球菌和几种革兰氏阴性菌（GNB）从个人的手在社区设置。在基线和年底，对随机分配使用抗菌清洁和卫生产品（包括含0.2%三氯生的洗手皂）或非抗菌清洁和卫生产品1年的个体进行手培养。尽管三氯生MIC与抗生素敏感性之间没有统计学显著相关性，但在基线时比较所有物种的比值比（OR），（OR = 0.65，95%置信区间[95%CI] = 0.33 - 1.27）与年底时相比（OR = 1.08，95%CI = 0.62 - 1.97）和基线时GNB单独给药（OR = 0.66，95%CI = 0.29 - 1.51）与年底（OR = 2.69，95%CI = 0.78 - 9.23）相比，无论使用何种洗手产品。此外，与家庭、临床和工业分离株的早期报告相比，某些菌种的三氯生MIC更高，其中一些分离株的三氯生MIC在消费品中使用的浓度范围内。三氯生MIC升高与抗生素敏感性降低之间不存在统计学显著相关性，可能表明这种相关性不存在，或者在所研究的分离株中相对较小。尽管如此，在社区环境中，细菌长期或高剂量暴露于三氯生后，可能会出现这种关系。
The possible association between triclosan and bacterial susceptibility to antibiotic was examined among staphylococci and several species of gram-negative bacteria (GNB) isolated from the hands of individuals in a community setting. Hand cultures from individuals randomized to using either antibacterial cleaning and hygiene products (including a hand soap containing 0.2% triclosan) or nonantibacterial cleaning and hygiene products for a 1-year period were taken at baseline and at the end of the year. Although there was no statistically significant association between triclosan MICs and susceptibility to antibiotic, there was an increasing trend in the association the odds ratios (ORs) for all species were compared at baseline (OR = 0.65, 95% confidence interval [95%CI] = 0.33 to 1.27) versus at the end of the year (OR = 1.08, 95%CI = 0.62 to 1.97) and for GNB alone at baseline(OR = 0.66, 95%CI = 0.29 to 1.51) versus the end of year (OR = 2.69, 95%CI = 0.78 to 9.23) regardless of the hand-washing product used. Moreover, triclosan MICs were higher in some of the species compared to earlier reports on household, clinical, and industrial isolates, and some of these isolates had triclosan MICs in the range of concentrations used in consumer products. The absence of a statistically significant association between elevated triclosan MICs and reduced antibiotic susceptibility may indicate that such a correlation does not exist or that it is relatively small among the isolates that were studied. Still, a relationship may emerge after longer-term or higher-dose exposure of bacteria to triclosan in the community setting.