Sickle cell trait and risk of cognitive impairment in African-Americans: The REGARDS cohort
Sickle cell trait and risk of cognitive impairment in African-Americans: The REGARDS cohort
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DOI：
10.1016/j.eclinm.2019.05.003
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发表时间：
2019-05-01
影响因子：
15.1
通讯作者：
Cushman, Mary
中科院分区：
文献类型：
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作者：
Cahill, Christina R.;Leach, Justin M.;Cushman, Mary
背景：镰状细胞性贫血可能与认知功能障碍有关，镰状细胞性贫血的一些并发症可能会影响镰状细胞性状（SCT）患者，因此我们假设 SCT 是认知障碍的危险因素。 方法：卒中地理和种族差异的原因 (REGARDS) 研究从 2003 年至 7 年间招募了 30,239 名美国白人和黑人，每 6 个月进行一次随访。基线和年度全球认知功能测试使用六项筛选器 (SIS)，这是一种经过验证的仪器（分数范围 0-6；0.11）。 解释：在这项针对美国黑人的前瞻性队列研究中，SCT 与认知障碍事件或学习、记忆和执行功能测试分数下降无关。 (C) 2019 年由爱思唯尔有限公司出版。
Background: Sickle cell anemia may be associated with cognitive dysfunction, and some complications of sickle cell anemia might affect those with sickle cell trait (SCT), so we hypothesized that SCT is a risk factor for cognitive impairment.Methods: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) study enrolled a national cohort of 30,239 white and black Americans from 2003 to 7, who are followed every 6 months. Baseline and annual global cognitive function testing used the Six-Item Screener (SIS), a validated instrument (scores range 0-6; 0.11).Interpretation: In this prospective cohort study of black Americans, SCT was not associated with incident cognitive impairment or decline in test scores of learning, memory and executive function. (C) 2019 Published by Elsevier Ltd.