THE P2Z PURINOCEPTOR - AN INTRIGUING ROLE IN IMMUNITY, INFLAMMATION AND CELL-DEATH
THE P2Z PURINOCEPTOR - AN INTRIGUING ROLE IN IMMUNITY, INFLAMMATION AND CELL-DEATH
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DOI：
10.1016/0167-5699(95)80045-x
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发表时间：
1995-11-01
期刊：
影响因子：
--
通讯作者：
DIVIRGILIO, F
中科院分区：
文献类型：
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作者：
DIVIRGILIO, F
许多免疫细胞和炎症细胞表达一种细胞外ATP的质膜受体，称为P2Z嘌呤受体，它似乎与质膜孔相连。除了它所赋予的对ATP介导的细胞毒性的显著易感性外，这种分子的生理作用通常尚不明确。该受体在人单核细胞中受干扰素γ上调，并且在巨噬细胞分化过程中也会表达。在此，弗朗西斯科·迪·维尔吉利奥讨论了有关该受体的最新信息，并提出它在免疫和炎症反应中可能发挥的作用。
Many immune and inflammatory cells express a plasma membrane receptor for extracellular ATP, termed the P2Z purinoceptor, which appears to be coupled to a plasma membrane pore. The physiological role of such a molecule is generally unknown, except for the striking susceptibility to ATP-mediated cytotoxicity that it confers. The receptor is upregulated in human monocytes by interferon gamma and is also expressed during macrophage differentiation. Here, Francesco Di Virgilio discusses recent information on this receptor, and suggests a possible role for it in the immune and inflammatory response.