Inhibition of beta-amyloid formation by haloperidol: a possible mechanism for reduced frequency of Alzheimer's disease pathology in schizophrenia.
Inhibition of beta-amyloid formation by haloperidol: a possible mechanism for reduced frequency of Alzheimer's disease pathology in schizophrenia.
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氟哌啶醇抑制 β-淀粉样蛋白形成：降低精神分裂症中阿尔茨海默氏病病理频率的可能机制。
DOI：
10.1046/j.1471-4159.1997.68010333.x
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发表时间：
1997
影响因子：
4.7
通讯作者：
Cordell,B
中科院分区：
文献类型：
--
作者：
Higaki,J;MurphyJr,GM;Cordell,B
一些报告表明，老年精神分裂症（SZ）患者阿尔茨海默病（AD）神经病理学的发生率显著降低，并且已提出用于治疗SZ的药物可能是负责的。AD病理学中的一个中心事件是β-淀粉样蛋白（Aβ）肽的形成，其通过其前体蛋白的酶促加工而衍生。氟哌啶醇是一种常用于治疗SZ的抗精神病药物，可作为选定蛋白酶的抑制剂;因此，我们检查了该化合物抑制培养细胞Aβ形成的能力。氟哌啶醇和氟哌啶醇（在较小程度上）以剂量依赖性方式抑制Aβ。这些结果可能解释了老年SZ患者AD神经病理改变的明显减轻，并提供了这种差异的可能机制。
Several reports have suggested that the frequency of Alzheimer's disease (AD) neuropathology is significantly reduced in elderly individuals with schizophrenia (SZ), and it has been proposed that medications used for treatment of SZ may be responsible. A central event in AD pathology is the formation of β‐amyloid (Aβ) peptide, which is derived by enzymatic processing of its precursor protein. Haloperidol, an antipsychotic medication commonly used in the treatment of SZ, can act as an inhibitor of select proteinases; hence, we examined the ability of this compound to inhibit Aβ formation by cultured cells. Haloperidol and, to a lesser extent, droperidol inhibited Aβ in a dose‐dependent manner. These results may explain the apparent reduction of AD neuropathological changes in elderly patients with SZ as well as provide a possible mechanism for this difference.