Comparative features of hepatitis C virus infection in humans and chimpanzees
Comparative features of hepatitis C virus infection in humans and chimpanzees
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DOI：
10.1007/bf00945027
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发表时间：
1997-01-01
期刊：
影响因子：
--
通讯作者：
Walker, CM
中科院分区：
文献类型：
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作者：
Walker, CM
人类丙型肝炎病毒感染的几个特征在黑猩猩模型中被概括。最重要的是，在这两个物种中，持续感染的频率很高，尽管有证据表明有细胞和体液免疫反应，病毒仍会复制。一个关键的区别是，在慢性感染的黑猩猩身上，坏死性炎症病变几乎总是轻微的，而在人类中，疾病谱非常广泛，从轻度到重度肝炎，以及需要移植的终末期肝硬化。了解这两个物种中持续性丙型肝炎的异同的基础可能对开发有效的预防和治疗丙型肝炎病毒感染具有重要意义。
Several features of human HCV infection are recapitulated in the chimpanzee model. Most importantly, the frequency of persistent infection is high in both species, and virus replication occurs despite evidence of cellular and humoral immune responses. A key difference is that necroinflammatory lesions in chronically infected chimpanzees are almost always mild, whereas in humans the disease spectrum is very wide, ranging from mild to severe hepatitis and end-stage cirrhosis requiring transplantation. Understanding the basis for both the similarities and differences in persistent hepatitis C in the two species will probably be important for the development of effective prevention and therapy of HCV infection.