SELECTIVITY OF THE PARKINSONIAN NEUROTOXIN MPTP - TOXIC METABOLITE MPP+ BINDS TO NEUROMELANIN
SELECTIVITY OF THE PARKINSONIAN NEUROTOXIN MPTP - TOXIC METABOLITE MPP+ BINDS TO NEUROMELANIN
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DOI：
10.1126/science.3080808
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发表时间：
1986-02-28
期刊：
影响因子：
56.9
通讯作者：
SNYDER, SH
中科院分区：
文献类型：
--
作者：
DAMATO, RJ;LIPMAN, ZP;SNYDER, SH
甲基苯基四氢吡啶（MPTP）选择性地破坏人类和其他灵长类动物黑质中含有黑色素的神经元细胞体。我们发现，甲基苯基吡啶（MPP+），MPTP的活性代谢产物，这是积累inneuronally的儿茶酚胺摄取系统，结合具有高亲和力的黑色素和神经黑色素。MPP+在细胞内与神经黑色素结合，可能会逐渐释放，导致黑质神经元的后续损伤。
Methylphenyltetrahydropyridine (MPTP) selectively destroys neuronal cell bodies in the melanin-containing substantia nigra of humans and other primates. We show that methylphenylpyridine (MPP+), an active metabolite of MPTP which is accumulated intraneuronally by the catecholamine uptake system, binds with high affinity to melanin and neuromelanin. MPP+ bound intracellularly to neuromelanin may be released gradually, resulting in subsequent damage to the neurons of the substantia nigra.