When galectins recognize glycans: from biochemistry to physiology and back again.
When galectins recognize glycans: from biochemistry to physiology and back again.
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DOI：
10.1021/bi201121m
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发表时间：
2011-09-20
期刊：
影响因子：
2.9
通讯作者：
Rabinovich, Gabriel A.
中科院分区：
文献类型：
--
作者：
Di Lella, Santiago;Sundblad, Victoria;Cerliani, Juan P.;Guardia, Carlos M.;Estrin, Dario A.;Vasta, Gerardo R.;Rabinovich, Gabriel A.
半乳糖凝集素是一类进化上保守的多功能聚糖结合蛋白，在过去的十年中，人们对它的研究越来越多。半乳糖凝集素在细胞内或细胞外发挥作用，作为关键的生物介质，能够监测在基本生物过程如细胞通讯、炎症、发育和分化期间细胞表面上发生的变化。它们高度保守的结构，精致的碳水化合物特异性和调节广泛生物过程的能力吸引了来自广泛学科的广泛科学家，包括生物化学，生物物理学，细胞生物学和生理学。然而，尽管巨大的努力，解剖这些聚糖结合蛋白的功能和特性，有限的信息，这些蛋白质的结构和生化方面如何影响生物功能。在这篇综述中，我们的目标是整合结构，生化和功能方面的这个令人困惑的和古老的家庭的聚糖结合蛋白，并讨论其在生理和病理设置的影响。
In the past decade, increasing efforts have been devoted to the study of galectins, a family of evolutionarily conserved glycan-binding proteins with multifunctional properties. Galectins function, either intracellularly or extracellularly, as key biological mediators capable of monitoring changes occurring on the cell surface during fundamental biological processes such as cellular communication, inflammation, development, and differentiation. Their highly conserved structures, exquisite carbohydrate specificity, and ability to modulate a broad spectrum of biological processes have captivated a wide range of scientists from a wide spectrum of disciplines, including biochemistry, biophysics, cell biology, and physiology. However, in spite of enormous efforts to dissect the functions and properties of these glycan-binding proteins, limited information about how structural and biochemical aspects of these proteins can influence biological functions is available. In this review, we aim to integrate structural, biochemical, and functional aspects of this bewildering and ancient family of glycan-binding proteins and discuss their implications in physiologic and pathologic settings.
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