Subfertility increases risk of testicular cancer: evidence from population-based semen samples.
Subfertility increases risk of testicular cancer: evidence from population-based semen samples.
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DOI：
10.1016/j.fertnstert.2015.10.027
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发表时间：
2016-02
影响因子：
6.7
通讯作者：
Hotaling JM
中科院分区：
文献类型：
--
作者：
Hanson HA;Anderson RE;Aston KI;Carrell DT;Smith KR;Hotaling JM
使用定义明确的精液参数进一步了解精液质量与癌症风险之间的关系。回顾性队列研究。1994年至2011年在犹他州进行的低生育力健康和辅助生殖（SHARE）研究。其中20，433名男性接受了精液分析（SA），20，433名生育对照样本在年龄和出生年份上均不匹配。所有癌症的风险，以及前列腺、睾丸和黑色素瘤的特定部位结果。相对于有生育能力的男性，SA男性患睾丸癌的风险增加（风险率比（HR）=3.3）。当使用个体精液参数对不育症的特征进行细化时，我们发现，相对于有生育能力的对照组，少精子症男性患癌症的风险增加。这种关联对于睾丸癌特别强，基于浓度（HR=11.9）和精子计数（HR=10.3），少精子症男性的风险增加。与有生育能力的男性相比，运动性（HR=4.1）、活力（HR=6.6）、形态学（HR=4.2）或总运动计数（HR=6.9）最低四分位数的男性具有更高的睾丸风险。精子浓度和计数在分布的第90百分位数（分别≥178 M/ml和≥579）和总活动计数（TMC）的男性患黑色素瘤的风险增加（HRConcentration=2.1; HRCount=2.7; HRTMC=2.0）。我们发现无精子症和生育男性之间的癌症风险没有差异。患有SA的男性患睾丸癌的风险增加，这取决于精液质量。与以前的工作不同，我们没有发现无精子症与癌症或睾丸癌风险增加之间的联系。生育力低下的男性患睾丸癌的风险增加，这取决于精液质量。我们没有发现无精子症与癌症或睾丸癌风险增加之间的联系。
To further understand the association between semen quality and cancer risk using well-defined semen parameters. Retrospective cohort study. Subfertility Heath and Assisted Reproduction (SHARE) study in Utah from 1994 to 2011. 20,433 men from that underwent semen analysis (SA) and a sample of 20,433 fertile controls matched on age and birth year none. Risk of all cancers, as well as site-specific results for prostate, testicular, and melanoma. Relative to fertile men, men with SA have an increased risk of testicular cancer (Hazard Rate Ratio (HR) =3.3). When the characterization of infertility is refined using individual semen parameters, we find that oligozoospermic men have an increased risk of cancer relative to fertile controls. This association is particularly strong for testicular cancer, with increased risk in men with oligozoospermia based on concentration (HR=11.9) and sperm count (HR=10.3). Men in the in the lowest quartile of motility (HR=4.1), viability (HR=6.6), morphology (HR=4.2) or total motile count (HR=6.9) have higher risk of testicular compared to fertile men. Men with sperm concentration and count in the 90th percentile of the distribution (≥178 M/ml and ≥579, respectively) and total motile count (TMC) have an increased risk of melanoma (HRConcentration=2.1; HRCount=2.7; HRTMC=2.0). We find no differences in cancer risk between azoospermic and fertile men. Men with SA have an increased risk of testicular cancer that varies by semen quality. Unlike prior work, we did not find an association between azoospermia and increased cancer or testicular cancer risk. Subfertile men have an increased risk of testicular cancer that varies by semen quality. We did not find an association between azoospermia and increased cancer or testicular cancer risk.