Effects of gender, ethnicity, body composition, and fat distribution on serum leptin concentrations in children
Effects of gender, ethnicity, body composition, and fat distribution on serum leptin concentrations in children
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DOI：
10.1210/jc.82.7.2148
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发表时间：
1997-07-01
影响因子：
5.8
通讯作者：
Goran, MI
中科院分区：
文献类型：
--
作者：
Nagy, TR;Gower, BA;Goran, MI
Ob蛋白瘦素已被证明与人类和动物体内脂肪的测量密切相关。研究表明，即使在控制了总脂肪和相对体脂和体重指数之后，血清瘦素浓度也存在性别和种族差异。我们假设血清瘦素浓度的性别和种族差异是由于身体组成和体脂分布的差异。我们测量了74名青春期前男孩和女孩（43名非洲裔美国人和31名高加索人）的空腹血清瘦素浓度、身体组成（通过双能x线吸收仪测量脂肪量和无脂肪量）和身体脂肪分布（通过计算机断层扫描测量腹内和腹外脂肪组织）。我们的研究结果表明，血清瘦素浓度的性别差异不能完全用体重指数、总脂肪量或相对身体成分的差异来解释。然而，当根据相对体成分（脂肪量和无脂量）和体脂肪分布（sc和腹内脂肪组织）的差异调整血清瘦素浓度时，性别不再对血清瘦素浓度有独立的影响。血清瘦素浓度不受种族的影响。因此，在比较血清瘦素浓度的组间差异时，有必要充分控制体组成和脂肪分布的组间差异。
The Ob protein leptin has been shown to be closely correlated with measures of body fat in humans and animals. Studies have suggested that there are both gender and ethnic differences in serum leptin concentrations, even after controlling for total and relative body fat and body mass index. We hypothesized that gender and ethnic differences in serum leptin concentrations are due to differences in both body composition and body fat distribution. We measured fasting serum leptin concentration, body composition (fat mass and fat-free mass by dual energy x-ray absorptiometry), and body fat distribution (intraabdominal and sc abdominal adipose tissue by computed tomography) in 74 prepubertal boys and girls (43 African-Americans and 31 Caucasians). Our results showed that gender differences in serum leptin concentrations could not be fully explained by differences in body mass index, total fat mass, or relative body composition. However, when serum leptin concentrations were adjusted for differences in relative body composition (fat mass and fat-free mass) and body fat distribution (sc and intraabdominal adipose tissue), gender no longer had an independent effect on the serum leptin concentration. Serum leptin concentrations were not influenced by ethnicity. Thus, when comparing group differences in serum leptin concentrations, it is necessary to adequately control for group differences in body composition and fat distribution.