Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar:: G6PD Mahidol (487G>A) is the most common variant in the Myanmar population
Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar:: G6PD Mahidol (487G>A) is the most common variant in the Myanmar population
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DOI：
10.1007/s10038-004-0187-7
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发表时间：
2004-10-01
影响因子：
3.5
通讯作者：
Kawamoto, F
中科院分区：
文献类型：
--
作者：
Matsuoka, H;Wang, JC;Kawamoto, F
我们对缅甸偏远地区的疟疾诊断和治疗情况进行了调查。通过手指针刺法收集了1,000多人的血液样本，其中121人（11%）被发现葡萄糖-6-磷酸脱氢酶（G6 PD）缺乏。在这121人中，有50人同意分析G6 PD基因组。我们读取这些受试者的G6 PD序列，发现45例G6 PD Mahidol（487 G>A），2例G6 PD科英布拉（592 C>T），2例G6 PD Union（1360 C>T），1例G6 PD Canton（1376 G>T）。结合我们以前报告的数据，91.3%（73/80）的G6 PD变体是G6 PD Mahidol。这一发现表明，缅甸人口来自同质祖先，并从泰国，马来西亚和印度尼西亚人口不同。
We conducted a survey of malaria diagnoses and treatments in remote areas of Myanmar. Blood specimens from more than 1,000 people were collected by the finger-prick method, and 121 (11%) of these people were found to be glucose-6-phosphate dehydrogenase (G6PD) deficient. Of these 121, 50 consented to analysis of the G6PD genome. We read the G6PD sequences of these subjects and found 45 cases of G6PD Mahidol (487G>A), two of G6PD Coimbra (592C>T), two of G6PD Union (1360C>T), and one of G6PD Canton (1376G>T). Taken together with data from our previous report, 91.3% (73/80) of G6PD variants were G6PD Mahidol. This finding suggests that the Myanmar population is derived from homogeneous ancestries and are different from Thai, Malaysian, and Indonesian populations.