Cytotoxic Cardenolide Glycosides from the Seeds of Antiaris toxicaria
Cytotoxic Cardenolide Glycosides from the Seeds of Antiaris toxicaria
复制标题
DOI：
10.1055/s-0030-1271045
复制
发表时间：
2011-10-01
期刊：
影响因子：
2.7
通讯作者：
Dai, Hao-Fu
中科院分区：
文献类型：
--
作者：
Dong, Wen-Hua;Mei, Wen-Li;Dai, Hao-Fu
对见血封喉（Antiaris toxicaria）种子的乙醇提取物进行生物活性导向分离，得到了三种新的强心苷，分别命名为见血封喉苷J（1）、见血封喉苷K（2）和见血封喉苷L（3），以及一种已知的葡萄糖毒毛旋花子苷（4）。通过高分辨电喷雾质谱（HRESIMS）、紫外（UV）、红外（IR）以及一维、二维核磁共振（1D, 2D NMR）等光谱方法阐明了新化合物的结构。评估了这些强心苷对人胃癌（SGC - 7901）和人肝癌（SMMC - 7721）细胞系的细胞毒活性，它们均表现出显著的细胞毒性。
Bioassay-guided fractionation of the ethanolic extract from the seeds of Antiaris toxicaria led to the isolation of three new cardiac glycosides named toxicarioside J (1), toxicarioside K (2), and toxicarioside L (3), together with a known glucostrophalloside (4). The structures of the new compounds were elucidated by spectroscopic methods including HRESIMS, UV, IR, and 1D, 2D NMR techniques. The cytotoxic activities of these cardiac glycosides against human gastric (SGC-7901) and human hepatoma (SMMC-7721) cell lines were evaluated, and all of them exhibited significant cytotoxicity.