Tiny Shuttles for Information Transfer: Exosomes in Cardiac Health and Disease.
Tiny Shuttles for Information Transfer: Exosomes in Cardiac Health and Disease.
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DOI：
10.1007/s12265-016-9682-4
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发表时间：
2016-06
影响因子：
3.4
通讯作者：
Gumpert A
中科院分区：
文献类型：
--
作者：
Kishore R;Garikipati VNS;Gumpert A
由外泌体（纳米大小的细胞外囊泡）介导的细胞间通讯对于保持血管完整性以及心血管和其他疾病的发展至关重要。作为信号分子的天然载体，从血细胞、内皮细胞、免疫细胞、平滑肌细胞等来源释放的外泌体可以改变多种细胞生物活性。它们通过在体液和细胞外空间中循环时在供体细胞和受体细胞之间穿梭脂质、蛋白质和核酸来实现这一点。最近人们对外泌体生物学领域的兴趣激增，部分原因是人们认识到它们携带的分子可以充当发病机制的促进剂，但也可以启动保护和救援信号传导。这篇小评论描述了外泌体在健康和疾病（包括心血管疾病）中的功能的最新知识。
Intercellular communication mediated by exosomes, nano-sized extracellular vesicles, is crucial for preserving vascular integrity and in the development of cardiovascular and other diseases. As natural carriers of signal molecules, exosomes released from sources such as blood cells, endothelial cells, immune cells, smooth muscle cells, etc., can modify a multitude of cellular bioactivities. They do so by shuttling lipids, proteins and nucleic acids between donor and recipient cells while circulating in body fluids and in the extracellular space. A recent surge of interest in the field of exosomal biology is in part due to the recognition that the molecules they carry can act as facilitators of both pathogenesis but can also initiate protective and rescue signaling. This mini-review describes current knowledge on exosome function in health and disease including cardiovascular disease.