Influence of y Irradiation on the Development of Neoplastic Disease in Mice
Influence of y Irradiation on the Development of Neoplastic Disease in Mice
复制标题
γ射线照射对小鼠肿瘤疾病发展的影响
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
J. Storer
中科院分区：
文献类型：
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作者：
R. Ullrich;J. Storer
用雄性和雌性RFM/un小鼠研究了~(137)Cs-γ射线照射对网状组织肿瘤发生的影响。辐射剂量和女性胸腺淋巴瘤发病率之间的关系是复杂的，没有简单的模型描述整个剂量范围内的关系。在0到25rad的范围内，可以不考虑线性，并且可以用剂量平方模型来描述数据，而在50到300rad的范围内，响应是线性的。男性对诱发胸腺淋巴瘤的敏感性低于女性，并且他们的剂量-反应关系不那么复杂，以线性反应为主。男性对诱发髓系白血病较女性敏感，300rad年龄调整发病率男性达20%，女性仅为5%。男性和女性的反应都是线性的。在雄性和雌性小鼠中，网状细胞肉瘤的年龄调整发病率都随着剂量的增加而下降。讨论了宿主因素在决定肿瘤类型以及剂量-反应关系形式中的作用。
The influence of 137Cs y irradiation on the development of reticular tissue neoplasms was investiged using male and female RFM/Un mice. The relationship between radiation dose and incidence of thymic lymphoma for females was complex, and no simple model described the relationship over the entire dose range. Over the range 0 to 25 rad linearity could be rejected and a dose-squared model described the data, while over the range 50 to 300 rad the response was linear. Males were less sensitive to induction of thymic lymphoma than females and their dose-response relationship was less complex with a linear response predominating. Males were more sensitive than females to induction of myeloid leukemia, with the age-adjusted incidence at 300 rad reaching 20% in males but only 5% in females. The response was linear for both sexes. The age-adjusted incidence of reticulum cell sarcoma decreased with dose in both male and female mice. The role of host factors in determining the type of neoplasm as well as the form of the dose-response relationship is discussed.