Associations between broader autism phenotype (BAP) and maternal attachment are moderated by maternal postpartum depression when infants are one month old: A prospective study of the Japan environment & children's study
Associations between broader autism phenotype (BAP) and maternal attachment are moderated by maternal postpartum depression when infants are one month old: A prospective study of the Japan environment & children's study
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DOI：
10.1016/j.jad.2018.09.060
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发表时间：
2019-01-15
影响因子：
6.6
通讯作者：
Iso, Hiroyasu
中科院分区：
文献类型：
--
作者：
Hirokawa, Kumi;Kimura, Takashi;Iso, Hiroyasu
背景：更广泛的自闭症表型（BAP）是指与自闭症谱系障碍类似的行为和认知倾向的表达。本研究调查了母亲的 BAP 是否与母性依恋前瞻性相关，以及产后抑郁症是否改变了这种关联。方法：日本环境与儿童研究 (JECS) 是一项由国家和政府资助的出生队列研究，于 2011 年 1 月开始。在 103,099 名入组母亲中，87,369 名没有抑郁症病史的母亲被纳入分析。使用自填问卷。其中包括：日本版自闭症谱系商数、母婴联结量表和爱丁堡产后抑郁量表。进行逻辑回归分析。结果：在调整混杂变量后，妊娠中期或晚期的 BAP 与婴儿一个月大时产后抑郁和母亲不安全依恋的风险增加呈线性相关（趋势 p < 0.001）。当按产后抑郁症分层时，在 BAP 分量表中，社交技能和沟通的缺陷与没有产后抑郁症的母亲不安全的母性依恋风险增加相关。在患有产后抑郁症的母亲中，BAP 子量表与母亲依恋之间的关系减弱。 局限性：本研究仅使用了母婴联结量表的五个项目，因此应谨慎解释结果。结论：母亲的 BAP 可以预测母亲对其婴儿的不安全依恋。产后抑郁症部分调节了母亲的 BAP 与不安全的母亲依恋之间的关联。
Background: Broader autism phenotype (BAP) refers to the expression of behavioral and cognitive dispositions similar to autism spectrum disorder. The present study investigated whether mothers' BAP was prospectively associated with maternal attachment, and if postpartum depression modified this association.Methods: The Japan Environment and Children's Study (JECS) is a national and government-funded birth cohort study that began in January 2011. Among the 103,099 mothers enrolled, 87,369 mothers without a history of depression were included in the analysis. Self-administered questionnaires were used. These included: the Japanese version of the Autism Spectrum Quotient, the Mother to Infant Bonding Scale, and the Edinburgh Postnatal Depression Scale. Logistic regression analyses were performed.Results: The BAP during the second or third trimester of pregnancy was linearly associated with an increased risk of postpartum depression and insecure maternal attachment when infants were one month old (p for trend < 0.001), after adjusting for confounding variables. When stratified by postpartum depression, among the BAP subscales, deficiencies in social skills and communication were associated with an increased risk of insecure maternal attachment in mothers without postpartum depression. The relationships between the BAP subscales and maternal attachment were attenuated among mothers with postpartum depression.Limitations: Only five items of the Mother to Infant Bonding Scale were used in the present study, and thus the results should be interpreted with caution.Conclusions: Mothers' BAP was predictive of insecure maternal attachment toward their infant. Postpartum depression partially moderated the associations between mothers' BAP and insecure maternal attachment.