Semisynthetic hydrophilic polyals.
Semisynthetic hydrophilic polyals.
复制标题
半合成亲水性聚醛。
DOI：
10.1021/bm0502157
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发表时间：
2005
影响因子：
6.2
通讯作者：
Fischman,AlanJ
中科院分区：
文献类型：
--
作者：
Papisov,MikhailI;Hiller,Alexander;Yurkovetskiy,Alexander;Yin,Mao;Barzana,Marlene;Hillier,Shawn;Fischman,AlanJ
非生物粘附性、完全可生物降解的可溶性聚合物将在先进的生物医学应用中发挥非常重要的作用，例如基因和药物输送以及组织工程。然而，由于高分子与生物环境相互作用的复杂性，阻碍了此类材料的合理开发。碳水化合物在自然形成的界面结构中的普遍存在表明了一种替代的仿生方法。界面碳水化合物，无论其生物学功能如何，都有共同的非信号亚结构(如缩醛和缩酮基团，仲醇和伯醇)。我们假设，由非信号碳水化合物亚结构构建的无环单元组成的亲水性聚合物(Polyals)将具有高度的生物相容性和非生物粘附性，而链内缩醛或缩酮基团将使细胞摄取后能够进行非酶生物降解。非环亲水聚合物可以通过合适的单体聚合或环状多聚物(例如，多糖)的侧向裂解来制备。在本研究中，通过多醛和多酮的侧向裂解制备了模型多聚物。以葡聚糖B-512为前驱体效果最好。得到的聚[羟甲基乙烯-羟甲基甲醛]与假设一致，表现出良好的生物学性能和工艺灵活性。这类材料可能在药理学和生物工程中有几个潜在的应用。
Nonbioadhesive, fully biodegradable soluble polymers would be very instrumental in advanced biomedical applications, such as gene and drug delivery and tissue engineering. However, rational development of such materials is hindered by the complexity of macromolecule interactions with biological milieu. The prevalence of carbohydrates in naturally occurring interface structures suggests an alternative, biomimetic approach. Interface carbohydrates, regardless of their biological function, have common nonsignaling substructures (e.g., acetal and ketal groups, secondary and primary alcohols). We hypothesized that hydrophilic polymers (polyals) consisting of acyclic units built of nonsignaling carbohydrate substructures would be highly biocompatible and nonbioadhesive, while intrachain acetal or ketal groups would enable nonenzymatic biodegradation upon uptake by cells. Acyclic hydrophilic polyals can be prepared via either polymerization of suitable monomers or lateral cleavage of cyclic polyals (e.g., polysaccharides). In this study, model polyals were produced via lateral cleavage of polyaldoses and polyketoses. Best results were achieved using dextran B-512 as a precursor. The resultant poly[hydroxymethylethylene hydroxymethylformal], in agreement with the hypothesis, demonstrated excellent biological properties and technological flexibility. Materials of this type can potentially have several applications in pharmacology and bioengineering.