Mechanoresponsive Drug Release from a Flexible, Tissue-Adherent, Hybrid Hydrogel Actuator.
Mechanoresponsive Drug Release from a Flexible, Tissue-Adherent, Hybrid Hydrogel Actuator.
复制标题
柔性、组织粘附、混合水凝胶致动器的机械响应药物释放。
DOI：
10.1002/adma.202303301
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Roche,EllenT
中科院分区：
文献类型：
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作者：
Mendez,Keegan;Whyte,William;Freedman,BenjaminR;Fan,Yiling;Varela,ClaudiaE;Singh,Manisha;Cintron-Cruz,JuanC;Rothenbücher,SandraE;Li,Jianyu;Mooney,DavidJ;Roche,EllenT
用于治疗性生物医学应用的软机器人技术需要适形和无损伤的组织耦合，以适应动态加载，以实现有效的药物输送或组织刺激。这种亲密和持续的接触为局部药物释放提供了巨大的治疗机会。在这里，介绍了一种新型的混合型水凝胶致动器(HHA)，它有助于增强药物的传递。该多材料软致动器可以通过时间控制从其海藻酸盐/丙烯酰胺水凝胶层中引发带电药物的可调谐机械响应释放。给药控制参数包括激励幅度、频率和持续时间。致动器可以通过一种灵活的、药物渗透的粘合剂安全地粘合在组织上，这种粘合剂可以承受动态设备的启动。混合水凝胶致动器与组织的共形粘附性改善了药物的机械响应性空间递送。未来将这种混合水凝胶致动器与其他软机器人辅助技术相结合，可以实现协同、多管齐下的疾病治疗方法。
Soft robotic technologies for therapeutic biomedical applications require conformal and atraumatic tissue coupling that is amenable to dynamic loading for effective drug delivery or tissue stimulation. This intimate and sustained contact offers vast therapeutic opportunities for localized drug release. Herein, a new class of hybrid hydrogel actuator (HHA) that facilitates enhanced drug delivery is introduced. The multi‐material soft actuator can elicit a tunable mechanoresponsive release of charged drug from its alginate/acrylamide hydrogel layer with temporal control. Dosing control parameters include actuation magnitude, frequency, and duration. The actuator can safely adhere to tissue via a flexible, drug‐permeable adhesive bond that can withstand dynamic device actuation. Conformal adhesion of the hybrid hydrogel actuator to tissue leads to improved mechanoresponsive spatial delivery of the drug. Future integration of this hybrid hydrogel actuator with other soft robotic assistive technologies can enable a synergistic, multi‐pronged treatment approach for the treatment of disease.