Immunotherapy and Hyperprogression: Unwanted Outcomes, Unclear Mechanism.

Immunotherapy and Hyperprogression: Unwanted Outcomes, Unclear Mechanism.
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DOI:
10.1158/1078-0432.ccr-18-3144
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发表时间:
2019-02-01
期刊:
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子:
--
通讯作者:
Ravetch JV
Ravetch JV
中科院分区:
其他
文献类型:
--
作者:
Knorr DA;Ravetch JV

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超进展(HP)是一种近期被定义的临床现象,即接受免疫治疗的患者矛盾地出现肿瘤快速生长的情况。尽管在这一问题上的近期研究指出Fc受体在这一过程中可能起作用,但超进展的机制仍不明确。
Hyperprogression (HP) is a recently defined clinical phenomenon in which patients treated with immunotherapy paradoxically exhibit rapid tumor growth. The mechanisms of HP remain ill-defined though recent studies in this issue point to a possible role for Fc receptors in this process.