Dietary Protein, Chronic Salt-Sensitive Hypertension, and Kidney Damage.
Dietary Protein, Chronic Salt-Sensitive Hypertension, and Kidney Damage.
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DOI：
10.34067/kid.0000000000000210
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发表时间：
2023-08-01
期刊：
影响因子：
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通讯作者：
Abais-Battad JM
中科院分区：
文献类型：
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作者：
Mattson DL;Dasinger JH;Abais-Battad JM
据估计，全世界五分之一以上的死亡可归因于饮食风险因素。一种特别严重的病症是盐敏感性（SS）高血压和肾损伤，其参与者表现出增加的发病率和死亡率。值得注意的是，来自人类和动物的大量证据表明，饮食的其他成分也可以调节高血压和相关的终末器官损伤。在这篇综述中提出的证据提供了支持的观点，即免疫和炎症有助于放大SS高血压的发展，并导致恶性疾病伴随组织损伤。有趣的是，SS高血压是通过饮食蛋白质摄入量的变化来调节的，这也影响免疫机制。总之，来自动物和人类研究的证据表明，膳食蛋白质来源的变化对肠道微生物群、微生物群衍生的代谢产物、基因表达、免疫细胞活化、细胞因子和其他因子的产生以及SS高血压和肾损害的发展具有深远的影响。
It has been estimated that over a fifth of deaths worldwide can be attributed to dietary risk factors. A particularly serious condition is salt-sensitive (SS) hypertension and renal damage, participants of which demonstrate increased morbidity and mortality. Notably, a large amount of evidence from humans and animals has demonstrated that other components of the diet can also modulate hypertension and associated end-organ damage. Evidence presented in this review provides support for the view that immunity and inflammation serve to amplify the development of SS hypertension and leads to malignant disease accompanied by tissue damage. Interestingly, SS hypertension is modulated by changes in dietary protein intake, which also influences immune mechanisms. Together, the evidence presented in this review from animal and human studies indicates that changes in dietary protein source have profound effects on the gut microbiota, microbiota-derived metabolites, gene expression, immune cell activation, the production of cytokines and other factors, and the development of SS hypertension and kidney damage.