Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM).
Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM).
复制标题
通过连续定量磁化率绘图 (QSM) 测量新的增强型多发性硬化症 (MS) 病变磁化率的纵向变化。
DOI：
10.1002/jmri.25144
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Wang Y
中科院分区：
文献类型：
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作者：
Zhang Y;Gauthier SA;Gupta A;Comunale J;Chia-Yi Chiang G;Zhou D;Chen W;Giambrone AE;Zhu W;Wang Y
应用定量易感性标测（QSM）技术测量多发性硬化（MS）病变易感性的纵向变化。该研究已获得我们的机构审查委员会的批准。使用3T扫描仪上的3D多回波梯度回波序列，在基线MRI和两年内对29例患者的随访MRI上测量新的Gd增强MS病变的定量敏感性值的纵向变化。采用配对t检验和广义估计方程（GEE）模型对纵向变化进行分析。相对于正常外观白色物质（NAWM）的病变敏感性值从基线MRI时Gd增强的3.61 ± 6.11 ppb变化到随访MRI时Gd未增强的20.42 ±10.23 ppb（P < 0.001）。MS病变易感性值随着病变从Gd增强到Gd不增强而显著增加，作为疾病生物标志物。
To measure the longitudinal change in multiple sclerosis (MS) lesion susceptibility using quantitative susceptibility mapping (QSM). The study was approved by our Institutional Review Board. Longitudinal changes in quantitative susceptibility values of new enhanced-with-Gd MS lesions were measured at baseline MRI and on a follow up MRI in 29 patients within two years using a 3D multiple echo gradient echo sequence on a 3T scanner. Paired t-test and the generalized estimating equations (GEE) model was used to analyze the longitudinal change. Lesion susceptibility values relative to normal appearing white matter (NAWM) changed from 3.61 ± 6.11 ppb when enhanced-with-Gd at the baseline MRI to 20.42 ±10.23 ppb when not-enhanced-with-Gd at the follow up MRI (P < 0.001). MS lesion susceptibility value increases significantly as the lesion evolves from enhanced-with-Gd to not-enhanced-with-Gd, serving as a disease biomarker.