Pregnancy-associated breast cancers: Do they differ from other breast cancers in young women?
Pregnancy-associated breast cancers: Do they differ from other breast cancers in young women?
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DOI：
10.1016/j.breast.2012.05.002
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发表时间：
2012-08-01
期刊：
影响因子：
3.9
通讯作者：
Rouzier, Roman
中科院分区：
文献类型：
--
作者：
Genin, Anne-Sophie;Lesieur, Benedicte;Rouzier, Roman
妊娠对妊娠相关性乳腺癌（PABC）病理生理学的影响尚不清楚。我们比较了PABC和与妊娠无关的乳腺癌的特征我们对2004年1月1日至12月31日期间接受乳腺癌治疗的43岁以下女性患者进行了回顾性图表分析，2010.我们比较了诊断时的年龄、局部区域浸润和组织学资料。我们记录了276例患者中的282例乳腺癌。41个肿瘤（14.5%）为PABC。PABC患者明显比非PABC患者年轻。与非PABC相比，PABC是晚期肿瘤（T3-4）的两倍，并且具有两倍的HER 2过度表达和激素阴性状态。在PABC中观察到的更具侵袭性的组织学特征，特别是在产后肿瘤和年龄大于35岁的女性中，似乎是与妊娠相关的直接结果。(c)2012爱思唯尔有限公司保留所有权利。
The impact of pregnancy in the physiopathology of pregnancy-associated breast cancer (PABC) is still unclear.We compared the characteristics of PABCs and breast cancers not associated with pregnancy (non-PABCs) in terms of their loco-regional invasion and histological phenotype.We conducted a retrospective chart review on women less than 43 years of age treated for breast cancer from January 1, 2004 to December 31, 2010. We compared age at diagnosis, loco-regional invasion and histological data.We recorded 282 breast cancers in 276 patients. Forty-one tumors (14.5%) were PABCs. PABC patients were significantly younger than non-PABC patients. Compared with the non-PABCs, PABCs were twice more frequent advanced tumors (T3-4) and have twice more frequent HER2 over-expression and hormone negative status.The more aggressive histological profile observed in the PABCs, especially in post-partum tumors and women older than 35 years of age, seems to be a direct consequence of the association with pregnancy. (c) 2012 Elsevier Ltd. All rights reserved.