Extreme genetic signatures of local adaptation during Lotus japonicus colonization of Japan
Extreme genetic signatures of local adaptation during Lotus japonicus colonization of Japan
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DOI：
10.1038/s41467-019-14213-y
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发表时间：
2020-01
影响因子：
16.6
通讯作者：
Niraj Shah;Tomomi Wakabayashi;Yasuko Kawamura;Cathrine Kiel Skovbjerg;Ming-Zhuo Wang;Yusdar Mustamin;Y. Isomura;Vikas Gupta;Haojie Jin;Terry Mun;N. Sandal;Fuyuki Azuma;E. Fukai;Ümit Seren;Shohei Kusakabe;Yuki Kikuchi;Shogo Nitanda;Takashi Kumaki;M. Hashiguchi;Hidenori Tanaka;A. Hayashi;Mads Sønderkær;K. L. Nielsen;Korbinian Schneeberger;B. Vilhjálmsson;R. Akashi;J. Stougaard;Shusei Sato;M. Schierup;S. Andersen
中科院分区：
文献类型：
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作者：
Niraj Shah;Tomomi Wakabayashi;Yasuko Kawamura;Cathrine Kiel Skovbjerg;Ming-Zhuo Wang;Yusdar Mustamin;Y. Isomura;Vikas Gupta;Haojie Jin;Terry Mun;N. Sandal;Fuyuki Azuma;E. Fukai;Ümit Seren;Shohei Kusakabe;Yuki Kikuchi;Shogo Nitanda;Takashi Kumaki;M. Hashiguchi;Hidenori Tanaka;A. Hayashi;Mads Sønderkær;K. L. Nielsen;Korbinian Schneeberger;B. Vilhjálmsson;R. Akashi;J. Stougaard;Shusei Sato;M. Schierup;S. Andersen
新栖息地的殖民化预计需要遗传适应，以克服环境挑战。在这里，我们使用全基因组重新测序和广泛的共同花园实验，调查人口和选择过程与日本的殖民化百脉根在过去的~20,000年。基于基因组变异的模式，我们推断殖民过程的细节，其中L。japonicus逐渐从亚热带环境扩散到日本北方更冷的气候。我们确定了基因组区域之间的极端遗传分化北方和南方亚群，并进行人口结构校正关联映射的表型性状在一个共同的花园。比较这些分析的结果，我们发现，极端亚群分化的签名重叠强烈越冬和开花时间性状的表型关联信号。我们的研究结果提供的证据表明，这些性状是殖民过程中选择的直接目标，并指向相关的候选基因。
Colonization of new habitats is expected to require genetic adaptations to overcome environmental challenges. Here, we use full genome re-sequencing and extensive common garden experiments to investigate demographic and selective processes associated with colonization of Japan byLotus japonicusover the past ~20,000 years. Based on patterns of genomic variation, we infer the details of the colonization process whereL. japonicusgradually spread from subtropical conditions to much colder climates in northern Japan. We identify genomic regions with extreme genetic differentiation between northern and southern subpopulations and perform population structure-corrected association mapping of phenotypic traits measured in a common garden. Comparing the results of these analyses, we find that signatures of extreme subpopulation differentiation overlap strongly with phenotype association signals for overwintering and flowering time traits. Our results provide evidence that these traits were direct targets of selection during colonization and point to associated candidate genes.