Brief report: Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma
Brief report: Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma
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DOI：
10.1056/nejmoa044307
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发表时间：
2005-02-17
影响因子：
158.5
通讯作者：
Farrar, J
中科院分区：
文献类型：
--
作者：
de Jong, MD;Van Cam, B;Farrar, J
在越南南部，一名四岁男孩出现严重腹泻，随后出现癫痫、昏迷，最后死亡。脑脊液每立方毫米含有 1 个白细胞，葡萄糖水平正常，蛋白质水平升高（0.81 克/升）。甲型禽流感 (H5N1) 的诊断是通过从脑脊液、粪便、咽喉和血清标本中分离病毒来确定的。该患者九岁的妹妹两周前死于类似的综合症。兄弟姐妹的临床诊断均为急性脑炎。两名患者就诊时都没有呼吸道症状。这些病例表明 H5N1 流感的谱系比之前认为的更广泛。
In southern Vietnam, a four-year-old boy presented with severe diarrhea, followed by seizures, coma, and death. The cerebrospinal fluid contained 1 white cell per cubic millimeter, normal glucose levels, and increased levels of protein (0.81 g per liter). The diagnosis of avian influenza A (H5N1) was established by isolation of the virus from cerebrospinal fluid, fecal, throat, and serum specimens. The patient's nine-year-old sister had died from a similar syndrome two weeks earlier. In both siblings, the clinical diagnosis was acute encephalitis. Neither patient had respiratory symptoms at presentation. These cases suggest that the spectrum of influenza H5N1 is wider than previously thought.