An analysis of the accuracy of the Cyberknife: A robotic nameless stereotactic radiosurgical system
An analysis of the accuracy of the Cyberknife: A robotic nameless stereotactic radiosurgical system
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DOI：
10.1097/00006123-200301000-00018
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发表时间：
2003-01-01
期刊：
影响因子：
4.8
通讯作者：
Heilbrun, MP
中科院分区：
文献类型：
--
作者：
Chang, SD;Main, W;Heilbrun, MP
目的：使用立体定向放射外科系统治疗颅内和颅外肿瘤和其他病变需要高度准确的目标识别和定位。本研究的目的是评价射波刀（Accuray，Inc.，桑尼维尔，CA），一种无框架、图像引导、立体定向放射外科系统。方法：射波刀放射外科系统的临床相关准确度或应用准确度基于1）射束输送准确度，其结合了机器人和摄像机图像跟踪系统，以及2）目标定位准确度，其结合了计算机断层扫描（CT）成像和治疗计划。临床相关的准确度可以通过向体模输送辐射剂量来测量，其中使用射波刀系统的所有组件（包括治疗计划软件、机器人、摄像机跟踪系统和直线加速器）在一组CT图像上定义目标。临床相关的准确性进行了测量，头部幻影装有包的辐射变色胶片。测量的准确度是从治疗计划到放射外科暴露体模中测量的剂量轮廓的位移。结果：2001年安装在斯坦福大学医学中心的第二代射波刀系统的平均误差测量值范围为0.7mm（CT层厚为0.625 mm）到1.97 mm（CT层厚为3.75 mm）。结论：当使用1.25 mm的CT切片厚度时，无框架、图像引导、第二代射波刀放射外科系统具有1.1 +/- 0.3 mm的临床相关精度。射波刀精度与当前基于框架的放射外科系统中已发表的定位误差相当。
OBJECTIVE: The use of stereotactic radiosurgical systems to treat intracranial and extracranial tumors and other lesions requires a high degree of accuracy in target identification and localization. The purpose of this study was to evaluate the total system accuracy of the CyberKnife (Accuray, Inc., Sunnyvale, CA), a frameless, image-guided, stereotactic radiosurgery system.METHODS: Clinically relevant accuracy or application accuracy of the CyberKnife radiosurgery system is based on 1) the beam delivery accuracy, which combines the robot and the camera image tracking system, and 2) target localization accuracy, which combines computed tomographic (CT) imaging and treatment planning. Clinically relevant accuracy can be measured by delivering a radiation dose to phantoms, in which the target is defined on a set of CT images using all components of the CyberKnife system, including the treatment planning software, the robot, the camera tracking system, and the linear accelerator. Clinically relevant accuracy was measured in head phantoms loaded with packs of radiochromic film. The accuracy measured is the displacement of the dose contours from the treatment plan to that measured in the radiosurgically exposed phantom.RESULTS: Measurements of mean errors of the second-generation CyberKnife system at Stanford University Medical Center, installed in 2001, ranged from 0.7 mm for a CT slice thickness of 0.625 mm to 1.97 mm for a CT slice thickness of 3.75 mm.CONCLUSION: The frameless, image-guided, second-generation CyberKnife radiosurgery system has a clinically relevant accuracy of 1.1 +/- 0.3 mm when CT slice thicknesses of 1.25 mm are used. CyberKnife precision is comparable to published localization errors in current frame-based radiosurgical systems.