Correlated Neural Activity and Encoding of Behavior across Brains of Socially Interacting Animals
Correlated Neural Activity and Encoding of Behavior across Brains of Socially Interacting Animals
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DOI：
10.1016/j.cell.2019.05.022
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发表时间：
2019-07-11
期刊：
影响因子：
64.5
通讯作者：
Hong, Weizhe
中科院分区：
文献类型：
--
作者：
Kingsbury, Lyle;Huang, Shan;Hong, Weizhe
社交互动涉及复杂的决策任务，这些任务由参与者之间动态的相互反馈形成。一个悬而未决的问题是，在社会互动个体的大脑中，是否会出现以及如何出现新的特性来影响社会决策。通过同时进行显微内窥镜钙成像对社会互动的小鼠，我们发现，动物表现出脑间相关的神经活动在前额叶皮层，依赖于正在进行的社会互动。活动同步性来自两个神经元群体，它们分别编码自己的行为和社交伙伴的行为。引人注目的是，在竞争环境中，中脑相关性预测了未来的社会互动以及优势关系。总之，我们的研究为啮齿类动物的中脑同步提供了确凿的证据，揭示了同步是如何从单细胞水平的活动中产生的，并提出了作为多动物系统的一种属性的中脑神经活动耦合在协调和维持个体之间的社会互动中的作用。
Social interactions involve complex decision-making tasks that are shaped by dynamic, mutual feedback between participants. An open question is whether and how emergent properties may arise across brains of socially interacting individuals to influence social decisions. By simultaneously performing microendoscopic calcium imaging in pairs of socially interacting mice, we find that animals exhibit interbrain correlations of neural activity in the prefrontal cortex that are dependent on ongoing social interaction. Activity synchrony arises from two neuronal populations that separately encode one's own behaviors and those of the social partner. Strikingly, interbrain correlations predict future social interactions as well as dominance relationships in a competitive context. Together, our study provides conclusive evidence for interbrain synchrony in rodents, uncovers how synchronization arises from activity at the single-cell level, and presents a role for interbrain neural activity coupling as a property of multi-animal systems in coordinating and sustaining social interactions between individuals.