Effects of Exposure to a 128-mT Static Magnetic Field on Glucose and Lipid Metabolism in Serum and Skeletal Muscle of Rats
Effects of Exposure to a 128-mT Static Magnetic Field on Glucose and Lipid Metabolism in Serum and Skeletal Muscle of Rats
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DOI：
10.1016/j.arcmed.2010.07.008
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发表时间：
2010-07-01
影响因子：
7.7
通讯作者：
Lambert, Karen
中科院分区：
文献类型：
--
作者：
Elferchichi, Miryam;Mercier, Jacques;Lambert, Karen
背景和目标。日益严重的环境污染可能参与了代谢紊乱发病率的增加。稳恒磁场是由于居民区和商业区暴露增加而出现的一个新的环境健康问题，但其对血清和骨骼肌代谢的影响在很大程度上尚不清楚。选用6~7周龄雄性Wistar大鼠12只，随机分为两组，每组10只。结果暴露于128mT SMF的动物血糖(血糖、乳酸升高，血浆胰岛素水平降低)和血脂(即血浆甘油升高)均有明显变化。在腹膜糖耐量试验中，SMF暴露的大鼠与假暴露的大鼠相比表现出显著更高的高血糖，尽管两组的胰岛素水平相似。在组织中，SMF暴露只引起糖酵解肌酶活性的显著变化，导致股四头肌和肝糖原含量显著下降，磷脂水平升高。这项研究提供的证据表明，中等强度的亚急性SWF暴露会导致糖和脂代谢的重要变化，值得进一步研究以评估长期后果。(C)Elsevier Inc.出版的2010年IMSS
Background and Aims. Increasing environmental pollution may participate in the growing incidence of metabolic disorders Static magnetic fields (SMFs) are an emerging environmental health issue due to increased exposure in residential and commercial areas, however, their metabolic effects in serum and skeletal muscle are largely unknown The aim of this study was to investigate the effect of SMF exposure on glucose and lipid metabolism in serum and skeletal muscles of ratsMethods. Twelve 6- to 7-week-old male Wistar rats were randomly divided into two groups Kits exposed to 128 mT SMF and sham-exposed rats. This moderate-intensity exposure was performed for 1 h/day for 15 consecutive days.Results Animals exposed to 128 mT SMF displayed significant changes in both glucose (ie increases in plasma glucose and lactate and decrease in plasma insulin levels) and lipid (i.e., increases in plasma glycerol. cholesterol and phospholipids but not triglyceride levels) metabolism During intraperitoneal glucose tolerance tests, SMF-exposed rats displayed significantly higher hyperglycemia compared to sham-exposed rats despite similar insulin levels in both groups. In tissues, SMF exposure induced significant alterations in enzyme activities only in glycolytic muscles and caused a significant decrease in quadriceps and liver glycogen content together with increased phospholipid levelsConclusions. This study provides evidence that subacute SWF exposure of moderate intensity induces important alterations of glucose and lipid metabolisms, which deserve further investigations to evaluate lone-term consequences. (C) 2010 IMSS Published by Elsevier Inc