Cell cycle checkpoints, genetic instability and cancer.
Cell cycle checkpoints, genetic instability and cancer.
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发表时间：
1993-04
影响因子：
14.5
通讯作者：
T. Weinert;David Lydall
中科院分区：
文献类型：
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作者：
T. Weinert;David Lydall
在细胞周期中，事件的顺序由称为检查点的控制来维持。有两个检查点对DNA损伤很敏感，一个在有丝分裂之前起作用，另一个在DNA复制之前起作用。这与癌症有关，因为检查点突变表现出遗传不稳定，而这种不稳定是许多癌症的特征。对正常细胞和癌细胞中检查点的研究表明，与中央细胞周期控制p34CDC2及其调节因子存在机械关系。我们认为这些基因和那些在DNA代谢中起作用的基因的突变可能会影响检查点的功能。检查点和癌症之间的另一个联系可能是P53蛋白，它似乎在G1-S检查点发挥作用。考虑设立检查站可能会为癌症治疗提供更有效的手段。
During the cell cycle, the order of events is maintained by controls termed checkpoints. Two checkpoints are sensitive to DNA damage, one that acts before mitosis and a second that acts before DNA replication. This is relevant to cancer because checkpoint mutants show genetic instability, and such instability is characteristic of many cancers. Studies of checkpoints in normal and cancer cells suggest a mechanistic relationship to the central cell cycle control p34CDC2 and its regulators. We suggest how mutations in these genes and those with a role in DNA metabolism may affect the function of checkpoints. A further link between checkpoints and cancer may be the p53 protein, which appears to function at the G1-S checkpoint. Consideration of checkpoints may provide more effective means for cancer treatment.