Neural responses to kindness and malevolence differ in illness and recovery in women with anorexia nervosa.
Neural responses to kindness and malevolence differ in illness and recovery in women with anorexia nervosa.
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DOI：
10.1002/hbm.23005
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发表时间：
2015-12
影响因子：
4.8
通讯作者：
Montague PR
中科院分区：
文献类型：
--
作者：
McAdams CJ;Lohrenz T;Montague PR
在神经性厌食症中，社会关系问题会导致疾病，而社会支持的改善则与康复有关。使用多轮信任游戏和 3T MRI，我们比较了三组女性在社会关系中的神经反应：神经性厌食症女性、神经性厌食症长期体重恢复的女性和健康对照女性。每轮都会计算与游戏中社交信号相关的替代标记，以评估每个受试者的关系是否正在改善（仁慈）或恶化（恶意）。与健康女性相比，目前患病和体重恢复的厌食症受试者的楔前叶和右角回对仁慈的神经反应均减弱，但仅在当前患病的受试者中，左侧梭状回对恶意的神经反应有所不同。接下来，使用全脑回归，我们确定了办公室评估，即积极的个性化偏差，在所有受试者组的仁慈期间，该评估与枕叶、楔前叶和后扣带回、双侧颞顶交界处和背侧前扣带回的神经活动呈负相关。积极的个性化偏见是一种自我报告措施，用于评估一个人将积极经历归因于其他人的程度。这些数据表明，感知善意的问题可能是与神经性厌食症的发展相关的一致特征，而识别恶意可能与康复有关。未来对健康人群和精神病人群的社会大脑功能的研究应该考虑将积极的个性化偏见作为与善意感知相关的神经差异的可能标志。
In anorexia nervosa, problems with social relationships contribute to illness, and improvements in social support are associated with recovery. Using the multiround trust game and 3T MRI, we compare neural responses in a social relationship in three groups of women: women with anorexia nervosa, women in long-term weight recovery from anorexia nervosa, and healthy comparison women. Surrogate markers related to social signals in the game were computed each round to assess whether the relationship was improving (benevolence) or deteriorating (malevolence) for each subject. Compared with healthy women, neural responses to benevolence were diminished in the precuneus and right angular gyrus in both currently-ill and weight-recovered subjects with anorexia, but neural responses to malevolence differed in the left fusiform only in currently-ill subjects. Next, using a whole-brain regression, we identified an office assessment, the positive personalizing bias, that was inversely correlated with neural activity in the occipital lobe, the precuneus and posterior cingulate, the bilateral temporoparietal junctions, and dorsal anterior cingulate, during benevolence for all groups of subjects. The positive personalizing bias is a self-report measure that assesses the degree with which a person attributes positive experiences to other people. These data suggest that problems in perceiving kindness may be a consistent trait related to the development of anorexia nervosa, whereas recognizing malevolence may be related to recovery. Future work on social brain function, in both healthy and psychiatric populations, should consider positive personalizing biases as a possible marker of neural differences related to kindness perception.