Tuning face perception with electrical stimulation of the fusiform gyrus.
Tuning face perception with electrical stimulation of the fusiform gyrus.
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DOI：
10.1002/hbm.23543
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发表时间：
2017-06
影响因子：
4.8
通讯作者：
Mehta AD
中科院分区：
文献类型：
--
作者：
Keller CJ;Davidesco I;Megevand P;Lado FA;Malach R;Mehta AD
梭状回（FG）是一个重要的节点，在人脸处理网络，但其因果关系的作用，在人脸感知的知识是目前有限的。最近的研究表明，施加到FG的高频刺激会扭曲人类受试者对面部的感知。然而，这个过程的时间在FG相对于刺激发作和FG的作用在面部感知的空间范围是未知的。在这里，我们调查的因果关系的FG在面部知觉的应用精确的，事件相关的电刺激高阶视觉领域，包括FG在六个人类受试者进行颅内监测癫痫。我们比较了单个短暂（100μs）电脉冲对FG和非面部选择性视觉区域对检测扭曲面部的速度和准确性的影响。短暂的电刺激施加到面部选择性网站并不影响准确性，但显着增加了反应时间（RT）检测面部扭曲。重要的是，RT只有在视觉开始后100 ms施加电刺激时才发生改变，并且在面部选择性部位而不是位置选择性部位。此外，施加到面部选择性区域的电刺激降低了视觉诱发电位的幅度和高伽马功率。总之，这些结果表明，在一个关键的时间窗口内的面部选择性区域的电刺激诱导延迟的面部知觉。这些发现支持了时间和空间特定的因果关系的面孔选择性领域的作用，并表示在面部知觉的电生理和行为之间的重要联系。
The fusiform gyrus (FG) is an important node in the face processing network, but knowledge of its causal role in face perception is currently limited. Recent work demonstrated that high frequency stimulation applied to the FG distorts the perception of faces in human subjects. However, the timing of this process in the FG relative to stimulus onset and the spatial extent of FG's role in face perception are unknown. Here, we investigate the causal role of the FG in face perception by applying precise, event-related electrical stimulation to higher order visual areas including the FG in six human subjects undergoing intracranial monitoring for epilepsy. We compared the effects of single brief (100μs) electrical pulses to the FG and non-face-selective visual areas on the speed and accuracy of detecting distorted faces. Brief electrical stimulation applied to face-selective sites did not affect accuracy but significantly increased the reaction time (RT) of detecting face distortions. Importantly, RT was altered only when electrical stimulation was applied 100ms after visual onset and in face-selective but not place-selective sites. Furthermore, electrical stimulation applied to face-selective areas decreased the amplitude of visual evoked potentials and high gamma power over this time window. Together, these results suggest that electrical stimulation of face-selective regions within a critical time window induces a delay in face perception. These findings support a temporally and spatially specific causal role of face-selective areas and signify an important link between electrophysiology and behavior in face perception.