Vascular network remodeling via vessel cooption, regression and growth in tumors
Vascular network remodeling via vessel cooption, regression and growth in tumors
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DOI：
10.1016/j.jtbi.2006.01.022
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发表时间：
2006-08-21
影响因子：
2
通讯作者：
Rieger, H.
中科院分区：
文献类型：
--
作者：
Bartha, K.;Rieger, H.
将正常组织中的规则血管系统转化为高度不均匀的肿瘤特异性毛细血管网络，通过结合肿瘤生长、血管共选择、新血管形成、血管塌陷和细胞死亡的理论模型来描述。在与人黑色素瘤中发现的血管形态一致的广泛参数下，观察到肿瘤划分为血管密度、直径和坏死不同的几个区域。与人类黑色素瘤的数据雅阁，该模型预测被视为癌症治疗中重要诊断工具的微血管密度（MVD）不一定决定肿瘤进展的克里思。相反，这表明原始组织的MVD以及单个肿瘤细胞的代谢需求在肿瘤生长的初始阶段起主要作用。(c)2006爱思唯尔有限公司保留所有权利。
The transformation of the regular vasculature in normal tissue into a highly inhomogeneous tumor specific capillary network is described by a theoretical model incorporating tumor growth, vessel cooption, neo-vascularization, vessel collapse and cell death. Compartmentalization of the tumor into several regions differing in vessel density, diameter and in necrosis is observed for a wide range of parameters in agreement with the vessel morphology found in human melanoma. In accord with data for human melanoma the model predicts that microvascular density (MVD), regarded as an important diagnostic tool in cancer treatment, does not necessarily determine the tempo of tumor progression. lnstead it is suggested that the MVD of the original tissue as well as the metabolic demand of the individual tumor cell plays the major role in the initial stages of tumor growth. (c) 2006 Elsevier Ltd. All rights reserved.