Opioid drug abuse and modulation of immune function: consequences in the susceptibility to opportunistic infections.
Opioid drug abuse and modulation of immune function: consequences in the susceptibility to opportunistic infections.
复制标题
DOI：
10.1007/s11481-011-9292-5
复制
发表时间：
2011-12
影响因子：
6.2
通讯作者：
Barke, Roderick A.
中科院分区：
文献类型：
--
作者：
Roy, Sabita;Ninkovic, Jana;Banerjee, Santanu;Charboneau, Richard Gene;Das, Subhas;Dutta, Raini;Kirchner, Varvara A.;Koodie, Lisa;Ma, Jing;Meng, Jingjing;Barke, Roderick A.
静脉吸毒者(IDU)感染率高于普通人群，是IDU人群发病和住院的主要原因。流行病学研究提供的数据表明，在注射吸毒者中，结核病和肺炎等机会性细菌感染以及艾滋病毒-1和肝炎等病毒感染的流行率增加。静脉药物滥用人群和接受医学显示的慢性阿片类药物治疗的患者的一个重要组成部分是阿片类药物的戒断。关于阿片类药物戒断背景下细菌毒力的数据表明，戒断的小鼠对沙门氏菌感染的反应缩短了存活时间，增加了细菌负荷。随着支持阿片类药物依赖及其免疫抑制作用的证据越来越多，必须了解阿片类药物发挥这些作用的机制，并确定将从对抗阿片类药物免疫抑制作用的干预措施中受益最大的风险人群。因此，重要的是改进现有的动物模型，使其与人类条件非常匹配，并通过仔细控制的人体研究来交叉验证这些发现。更好地了解这些机制将有助于寻找新的治疗方式来抵消不良影响，包括增加感染率。本文综述了吗啡对先天免疫和获得性免疫的影响，确定了Mu阿片受体在这些功能中的作用以及在此过程中激活的信号转导。阿片类药物戒断在免疫抑制中的作用以及这些发现的临床相关性也将被讨论。
Infection rate among intravenous drug users (IDU) is higher than the general public, and is the major cause of morbidity and hospitalization in the IDU population. Epidemiologic studies provide data on increased prevalence of opportunistic bacterial infections such as TB and pneumonia, and viral infections such as HIV-1 and hepatitis in the IDU population. An important component in the intravenous drug abuse population and in patients receiving medically indicated chronic opioid treatment is opioid withdrawal. Data on bacterial virulence in the context of opioid withdrawal suggest that mice undergoing withdrawal had shortened survival and increased bacterial load in response to Salmonella infection. As the body of evidence in support of opioid dependency and its immunosuppressive effects is growing, it is imperative to understand the mechanisms by which opioids exert these effects and identify the populations at risk that would benefit the most from the interventions to counteract opioid immunosuppressive effects. Thus, it is important to refine the existing animal model to closely match human conditions and to cross-validate these findings through carefully controlled human studies. Better understanding of the mechanisms will facilitate the search for new therapeutic modalities to counteract adverse effects including increased infection rates. This review will summarize the effects of morphine on innate and adaptive immunity, identify the role of the mu opioid receptor in these functions and the signal transduction activated in the process. The role of opioid withdrawal in immunosuppression and the clinical relevance of these findings will also be discussed.
登录
查看更多内容
影响因子：
3.3
作者：
Boerner, Christine;Stumm, Ralf;Kraus, Juergen
通讯作者：
Kraus, Juergen
影响因子：
3.8
作者：
Breslow, Jessica M.;Feng, Pu;Eisenstein, Toby K.
通讯作者：
Eisenstein, Toby K.
影响因子：
3.7
作者：
Brichacek, Beda;Vanpouille, Christophe;Margolis, Leonid
通讯作者：
Margolis, Leonid
影响因子：
5
作者：
Anthony, IC;Ramage, SN;Bell, JE
通讯作者：
Bell, JE
影响因子：
5.6
作者：
Borman, Andrzej;Ciepielewski, Ziemowit;Tokarski, Juliusz
通讯作者：
Tokarski, Juliusz