Identification of novel psychoactive drug use in Sweden based on laboratory analysis - initial experiences from the STRIDA project
Identification of novel psychoactive drug use in Sweden based on laboratory analysis - initial experiences from the STRIDA project
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DOI：
10.3109/00365513.2013.793817
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发表时间：
2013-08-01
影响因子：
2.1
通讯作者：
Hulten, Peter
中科院分区：
文献类型：
--
作者：
Helander, Anders;Beck, Olof;Hulten, Peter
瞄准该研究旨在收集关于新精神活性物质使用增加的信息，这些物质通常通过网上商店作为“互联网药物”或“法律的兴奋剂”出售，或者作为“浴盐”和“植物食品”等伪装产品出售。方法.卡罗林斯卡研究所和卡罗林斯卡大学实验室以及瑞典毒物信息中心启动了一个名为“STRIDA”的项目，旨在监测瑞典境内新型精神活性物质的发生情况和趋势，并收集关于其临床症状、毒性和相关健康风险的信息。已经开发了液相色谱-串联质谱（LC-MS/MS）多组分方法，目前允许测定> 80种新型精神活性化合物或其代谢物。本研究主要关注已鉴别的特定原料药和初始STRIDA病例的人群人口统计学。结果在全国各地急诊科就诊的103例连续收治或疑似娱乐性药物中毒病例中，大多数是年轻受试者（78%< 25岁，81%为男性），在尿样和/或血样中检测到精神活性物质，占82%。这些物质包括合成大麻素（“香料”; JWH类似物）、取代的卡西酮（“浴盐”;例如丁酮、MDPV和甲酮）和色胺（4-HO-MET）、植物类物质（mitragynine和psilocin）以及常规滥用药物。在44%的案件中，检测到一种以上的新型精神活性物质，或新型和/或传统药物的混合物。结论STRIDA项目的初步结果记录了瑞典各地主要是年轻人使用各种新型精神活性物质的情况。
Aim. The study aimed to collect information concerning the increasing use of new psychoactive substances, commonly sold through online shops as 'Internet drugs' or 'legal highs', or in terms of masked products such as 'bath salts' and 'plant food'. Methods. The Karolinska Institutet and Karolinska University Laboratory and the Swedish Poisons Information Centre have initiated a project called 'STRIDA' aiming to monitor the occurrence and trends of new psychoactive substances in Sweden, and collect information about their clinical symptoms, toxicity and associated health risks. A liquid chromatographic-tandem mass spectrometric (LC-MS/MS) multi-component method has been developed, currently allowing for the determination of > 80 novel psychoactive compounds or metabolites thereof. This study focused mainly on the particular drug substances identified and the population demographics of the initial STRIDA cases. Results. In urine and/or blood samples obtained from 103 consecutive cases of admitted or suspected recreational drug intoxications in mostly young subjects (78% were < 25 years, and 81% were males) presenting at emergency departments all over the country, psychoactive substances were detected in 82%. The substances comprised synthetic cannabinoids ('Spice'; JWH analogues), substituted cathinones ('bath salts'; e.g. butylone, MDPV and methylone) and tryptamines (4-HO-MET), plant-based substances (mitragynine and psilocin), as well as conventional drugs-of-abuse. In 44% of the cases, more than one new psychoactive substance, or a mixture of new and/or conventional drugs were detected. Conclusion. The initial results of the STRIDA project have documented use of a broad variety of new psychoactive substances among mainly young people all over Sweden.