FUS colocalizes with polyglutamine, but not with TDP-43 in neuronal intranuclear inclusions in spinocerebellar ataxia type 2.
FUS colocalizes with polyglutamine, but not with TDP-43 in neuronal intranuclear inclusions in spinocerebellar ataxia type 2.
复制标题
在 2 型脊髓小脑共济失调的神经元核内包涵体中，FUS 与聚谷氨酰胺共定位，但不与 TDP-43 共定位。
DOI：
10.1111/nan.12075
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Wakabayashi K.
中科院分区：
文献类型：
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作者：
Mori F;Toyoshima Y;Tanji K;Kakita A;Takahashi H;Wakabayashi K.
本文提供了FUS的特性信息，FUS是多聚谷氨酰胺（polyQ）疾病中神经元核内包涵体（NIIs）的一种成分，与TDP-43（一种结合人类免疫缺陷病毒的细胞蛋白）具有相互关系。它讨论了几个事实，其中包括类别的额颞叶变性（FTLD），FUS免疫组化和核质和细胞质的包涵体轴承神经元，提出零FUS免疫反应。
The article offers information on the properties of FUS which is a component of neuronal intranuclear inclusions (NIIs) in polyglutamine (polyQ) diseases which has reciprocal relationship with TDP-43, a cellular protein that binds human immunodeficiency virus. It discusses several facts which includes categories of frontotemporal lobar degeneration (FTLD), FUS immunohistochemistry and nucleoplasm and cytoplasm of inclusion-bearing neurones that presents zero FUS immunoreactivity.