THE USE OF THERMORESPONSIVE HYDROGELS FOR ON-OFF RELEASE OF MOLECULES
THE USE OF THERMORESPONSIVE HYDROGELS FOR ON-OFF RELEASE OF MOLECULES
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DOI：
10.1016/0168-3659(95)00035-7
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发表时间：
1995-10-01
影响因子：
10.8
通讯作者：
DEMANUELE, A
中科院分区：
文献类型：
--
作者：
DINARVAND, R;DEMANUELE, A
描述了两种响应性递送装置，分子的释放取决于环境的温度。该装置利用具有较低临界溶解温度（LCST）的温敏水凝胶。描述了一种基于使用温度响应阀的新型温度响应装置，其中仅在高于水凝胶的LCST的温度下才发生分子的显著释放。还制备了温度响应性水凝胶盘，其中分子的显著释放仅在低于水凝胶的LCST的温度下发生。发现分子从两种装置（基于温度响应阀的装置和盘）的释放可以通过改变环境温度来控制。
Two responsive delivery devices are described from which the release of molecules is dependent on the temperature of the milieu. The devices utilise thermoresponsive hydrogels which possess a lower critical solution temperature (LCST). A novel thermoresponsive device based on the use of a thermoresponsive valve is described from which significant release of molecules only occurs at temperatures above the LCST of the hydrogel. Thermoresponsive hydrogel discs were also prepared from which significant release of molecules only occurs at temperatures below the LCST of the hydrogel. It was found that the release of molecules from both devices, the thermoresponsive valve-based device and the discs, could be controlled by changing the environmental temperature.