Regional expansion of oleic acid-injured lungs
Regional expansion of oleic acid-injured lungs
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DOI：
10.1164/ajrccm.160.1.9808101
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发表时间：
1999-07-01
影响因子：
24.7
通讯作者：
Hubmayr, RD
中科院分区：
文献类型：
--
作者：
Martynowicz, MA;Minor, TA;Hubmayr, RD
已有研究表明，在机械通气期间，受损肺的依赖区域塌陷，并受到循环重新开放和塌陷的影响。为了验证这一假设，我们测量了油酸（OA）损伤犬脑叶扩张的时空异质性。在OA损伤前后的肺闭环正弦振荡期间，使用肺内标记技术测量了9只狗（7只仰卧，2只俯卧）的局部体积。与计算机断层扫描相比，实质标记技术提供了区域组织尺寸的绝对测量，而不是区域空气与液体含量的相对测量。实验产生了三个主要发现：(1)OA损伤没有导致FRC依赖肺单元的塌陷；(2)OA损伤没有使FRC区域肺体积的垂直梯度变陡；(3)在FRC OA损伤肺的正弦振荡过程中，依赖区域没有发生循环重开和塌陷。基于这些结果，我们提出了损伤后区域阻抗的地形变化和肺扩张的另一种机制，即传导气道中的液体和泡沫。
It has been suggested that dependent regions of an injured lung are collapsed and subject to cyclic reopening and collapse during mechanical ventilation. To test this hypothesis, we measured both temporal and spatial heterogeneity of lobar expansion in oleic acid (OA)-injured dogs. Regional volumes were measured in nine dogs (seven supine and two prone) during closed loop sinusoidal oscillations of the lungs before and after OA injury using the parenchymal marker technique. In contrast to computer tomography, the parenchymal marker technique provides absolute measures of regional tissue dimensions as opposed to relative measures of regional air to liquid content. The experiments generated three major findings: (1) OA injury did not lead to the collapse of dependent lung units at FRC, (2) OA injury did not steepen the vertical gradient in regional lung volumes at FRC, and (3) during sinusoidal oscillation of the OA-injured lungs from FRC, dependent regions did not undergo cyclic reopening and collapse. On the basis of these results, we propose an alternative mechanism for the topographic variability in regional impedances and lung expansion after injury, namely liquid and foam in conducting airways.