Determining the compression behaviour of pharmaceutical powders from the force-distance compression profile
Determining the compression behaviour of pharmaceutical powders from the force-distance compression profile
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DOI：
10.1016/s0378-5173(02)00665-8
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发表时间：
2003-02-18
影响因子：
5.8
通讯作者：
Yliruusi, J
中科院分区：
文献类型：
--
作者：
Antikainen, O;Yliruusi, J
对偏心压片机的力-位移曲线进行了新的检验。材料的塑性变形、破碎和弹性趋势以数值表示，这些数值在不同材料之间具有可比性。这些数值对压缩压力的依赖性进行了建模。通过一种新的方法滤除测量数据中的噪声，提高了位移测量的精度。从该精确的位移数据可以准确地看到压缩循环的力最大值附近的材料的塑性变形。压片机的弹性变形也由运行的机器非常精确地定义。使用固定的下冲和上冲调节，用偏心压片机制备片剂。这确保了所有压实的上冲头速度和片剂的理论高度相同。因此，只有材料的性质决定了压缩曲线形状的差异。所用试验材料为α-乳糖一水合物、两种级别的微晶纤维素、玉米淀粉和磷酸二钙二水合物。结果表明，使用精确的位移测量是必不可少的，以便看到在压缩循环的力最大值附近的力-位移曲线的形状的小变化，并且它使得能够动态校准压缩期间偏心压片机的弹性变形。结果表明，在较宽的压缩压力范围内，用新方法得到的数值能较好地描述试验材料的塑性、脆性和弹性特性。(C)2002 Elsevier Science B. V.保留所有权利。
The force-displacement curves obtained from an eccentric tablet machine were examined in a new way. The tendency of the material for plastic deformation, fragmentation and elasticity is expressed as numerical values, which are comparable between different materials. The dependence of these numerical values on the compression pressure was modelled. The accuracy of the displacement measurement was improved by filtering out noise from the measurement data by a novel method. The plastic deformation of the material near the force maximum of the compression cycle could be seen accurately from this precise displacement data. The elastic deformation of the tablet machine was also defined very precisely from the running machine. Tablets were made with an eccentric tablet machine using fixed lower and upper punch adjustments. This ensured that the speed of the upper punch and the theoretical height of the tablets were the same for all compactions. Therefore, only the properties of the materials determined the differences in the shape of the compression curves. The test materials used were alpha-lactose monohydrate, two grades of microcrystalline cellulose, maize starch and dicalcium phosphate dihydrate. The results showed that the use of accurate displacement measurement is essential in order, to see the small variations in the shape of the force-displacement curve near the force maximum of the compression cycle, and it made it possible to dynamically calibrate the elastic deformation of the eccentric tablet machine during compression. It turned out that the numerical values obtained with the new method described the plastic, brittle and elastic properties of the tested materials satisfactorily in a wide compression pressure range. (C) 2002 Elsevier Science B.V. All rights reserved.