Neuronal responses to a delayed-response delayed-reward go/nogo task in the monkey posterior insular cortex
Neuronal responses to a delayed-response delayed-reward go/nogo task in the monkey posterior insular cortex
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DOI：
10.1016/j.neuroscience.2006.08.008
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发表时间：
2006-12-01
期刊：
影响因子：
3.3
通讯作者：
Nishijo, H.
中科院分区：
文献类型：
--
作者：
Asahi, T.;Uwano, T.;Nishijo, H.
岛叶皮层的解剖学连接表明它参与认知、情感、记忆和行为表现。然而，在灵长类动物的岛叶皮层中，很少有神经生理学研究与这些高级认知功能有关。在本研究中，神经活动记录从猴岛叶皮层在delayedresponse delayed-reward go/nogo任务的性能。在这项任务中，视觉刺激指示去或不去的反应与奖励（奖励试验）和无奖励（无奖励试验）后，眼睛注视。在奖励试验中，猴子被要求在延迟期（延迟1）后的第二次视觉刺激期间释放按钮。之后，又有一次延迟（延迟2）后的果汁奖励被交付。结果表明，在每个时代的任务的神经元响应地形定位在岛叶皮层，与以前的解剖研究表明地形分布的传入输入从其他皮层下和皮层感觉区。此外，一些岛叶神经元1）非特异性地对视觉线索和注视期间作出反应; 2）对预测奖励的视觉线索和奖励传递前的延迟期间作出反应; 3）在延迟2期间的go/nogo试验中作出差异反应; 4）在按钮操作周围作出反应。所观察到的模式的岛屿神经元的反应和对应的地形定位到以前的解剖学研究表明，岛叶皮层参与注意和奖励相关的功能，并可能监测和整合活动的其他大脑区域在认知和行为表现。(c)2006年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Anatomical connections of the insular cortex suggest its involvement in cognition, emotion, memory, and behavioral manifestation. However, there have been few neurophysiological studies on the insular cortex in primates, in relation to such higher cognitive functions. In the present study, neural activity was recorded from the monkey insular cortex during performance of a delayedresponse delayed-reward go/nogo task. In this task, visual stimuli indicating go or nogo responses associated with reward (reward trials) and with no reward (no-reward trials) were presented after eye fixation. In the reward trials, the monkey was required to release a button during presentation of the 2nd visual stimuli after a delay period (delay 1). Then, a juice reward was delivered after another delay (delay 2). The results indicated that the neurons responding in each epoch of the task were topographically localized within the insular cortex, consistent with the previous anatomical studies indicating topographical distributions of afferent inputs from other subcortical and cortical sensory areas. Furthermore, some insular neurons 1) nonspecifically responded to the visual cues and during fixation; 2) responded to the visual cues predicting reward and during the delay period before reward delivery; 3) responded differentially in go/nogo trials during the delay 2; and 4) responded around button manipulation. The observed patterns of insular-neuron responses and the correspondence of their topographical localization to those in previous anatomical studies suggest that the insular cortex is involved in attention- and reward-related functions and might monitor and integrate activities of other brain regions during cognition and behavioral manifestation. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.