Correlates of change in cognitive function in survivors from the Western Collaborative Group Study
Correlates of change in cognitive function in survivors from the Western Collaborative Group Study
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DOI：
10.1159/000109699
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发表时间：
1997-11-01
影响因子：
5.7
通讯作者：
Eslinger, PJ
中科院分区：
文献类型：
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作者：
Carmelli, D;Swan, GE;Eslinger, PJ
在基线时对566名65-86岁的受试者的认知功能变化进行了研究，这些受试者是西方协作组研究的子样本，这是一项始于20世纪60年代的中年男性心血管流行病学研究。认知功能评估在1986-1988年（基线），并再次在1992-1994年通过三个标准化的措施：本顿视觉保持测试，控制的口头文字联想测试，和数字符号替代（DSS）测试。纵向变化的表现被定义为随着时间的推移，在一个主题的四分位数排序的变化，使用基线分布的测试分数作为标准。认知功能的“下降者”和“改善者”分别是在所有三项测试中失去或获得两个或更多四分位数排名的受试者。根据这一定义，20%（n = 113）的受试者下降，而17%（n = 95）的受试者从1986-1988年到1992-1994年的认知表现有所改善。在调整了年龄、教育和身体健康因素后，认知能力的下降与自我感觉健康评分、抑郁量表评分和自我报告的身体活动显著相关。在一系列不同的神经心理学测试中，DSS测试中的等级分数变化是随访时认知功能的最佳预测因素。
Changes in cognitive function were investigated in 566 subjects 65-86 years old at baseline, who are a subsample of the Western Collaborative Group Study, a cardiovascular epidemiologic study of middle-aged men that began in the 1960s. Cognitive function was assessed in 1986-1988 (baseline) and again in 1992-1994 by three standardized measures: the Benton Visual Retention Test, the Controlled Oral Word Association Test, and the Digit Symbol Substitution (DSS) Test. Longitudinal change in performance was defined as the shift over time in a subject's quartile rank ordering, using the baseline distribution of test scores as a standard. 'Decliners' and 'improvers' in cognitive function were subjects who lost or gained, respectively, two or more quartile ranks on all three tests combined. By this definition, 20% (n = 113) of subjects declined, compared with 17%(n = 95)who improved in cognitive performance from 1986-1988 to 1992-1994. After adjustment for age, education, and physical health, decline in cognitive performance was significantly associated with poor self-perceived health ratings, depression scale scores, and self-reports of physical activity. Rank score change in the DSS Test was the single best predictor of cognitive function at follow-up on a diverse battery of neuropsychological tests.