Dynamics of cytokines and lymphocyte subsets associated with the poor prognosis of severe COVID-19
Dynamics of cytokines and lymphocyte subsets associated with the poor prognosis of severe COVID-19
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DOI：
10.26355/eurrev_202012_24051
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发表时间：
2020-12-01
影响因子：
3.3
通讯作者：
Chen, L.
中科院分区：
文献类型：
--
作者：
Li, Q.;Xu, W.;Chen, L.
目的：研究重症COVID-19患者细胞因子和淋巴细胞亚群的动态变化及其与预后的关系。患者与方法：对31例重症COVID-19患者（死亡7例，存活24例）的淋巴细胞亚群和细胞因子进行纵向分析。结果：入组患者平均年龄为64岁。男性24例（77.4%），合并合并症23例（74.2%）。与生存组比较。死亡组患者IL-6、IL-8、IL-10水平从基线至入院后28天持续显著升高（均p0.05）。从入院至入院后3 d，生存组和死亡组患者CD3+ T细胞、CD4+ T细胞、CD8+ T细胞、CD45+ T细胞的绝对计数均较低，生存组患者在入院后4 ~ 35 d逐渐恢复，死亡组患者在随访期间持续处于低水平。结论：细胞因子和淋巴细胞亚群的动力学变化与重症COVID-19患者的预后有关。
OBJECTIVE: We aimed to study the dynamics of cytokines and lymphocyte subsets and their correlation with the prognosis of patients with severe COVID-19.PATIENTS AND METHODS: The lymphocyte subsets and cytokines of 31 patients with severe COVID-19 (7 deaths and 24 survivals) were longitudinally analyzed.RESULTS: The mean age of enrolled patients was 64 years. 24 (77.4%) patients were men, and 23 (74.2%) patients had comorbidities. Compared with survival group. the death group showed significant and sustained increases in the levels of IL-6, IL-8, and IL-10 from baseline to 28 days after admission (all p0.05). The absolute counts of CD3+ T cells, CD4+ T cells, CD8+ T cells, and CD45+ T cells were lower in both survival group and death group patients from hospital admission to 3 days after admission, and gradually recovered in 4 to 35 days in the survival group, but continually stayed at low levels in the death group during the follow-up.CONCLUSIONS: The kinetic changes of cytokines and lymphocyte subsets are related with the prognosis of patients with severe COVID-19.