A Case of IgG4-Related Disease Admitted with CRP Elevation of Unknown Origin
A Case of IgG4-Related Disease Admitted with CRP Elevation of Unknown Origin
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因 CRP 不明原因升高而入院的 IgG4 相关疾病一例
DOI：
10.14789/jmj.62.228
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
T. Naito
中科院分区：
文献类型：
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作者：
A. Inui;T. Naito
我们描述的情况下，一个32岁的男子c反应蛋白（CRP）升高的不明原因，谁被转移到Juntendo大学医院怀疑全身性病毒感染。全身CT显示主动脉旁淋巴结、髂总淋巴结及腋窝淋巴结肿大。实验室数据显示免疫球蛋白（Ig）G4水平升高。腋窝淋巴结活检检查疑似igg4相关疾病，发现igg4阳性浆细胞明显浸润。最近有了各种成像方式和实验室测试。然而，大多数肿瘤疾病需要侵入性检查，如活检，以达到明确的诊断。临床医生应毫不犹豫地获得病理标本，以明确诊断疑似肿瘤疾病的患者。
We describe the case of a 32-year-old man with C-reactive protein (CRP) elevation of unknown origin who was transferred to Juntendo University Hospital on suspicion of systemic viral infection. Whole-body computed tomography (CT) showed enlargement of the para-aortic, common iliac and axillary lymph nodes. Laboratory data showed elevated levels of immunoglobulin (Ig)G4. Axillary lymph node biopsy was performed to investigate suspected IgG4-related disease, revealing marked infiltration of IgG4-positive plasma cells. Various imaging modalities and laboratory tests have recently become available. However, most neoplastic diseases need invasive testing such as biopsy to reach a definitive diagnosis. Clinicians should not hesitate to obtain pathological specimens to definitively diagnose patients with suspected neoplastic disease.