TRP channels in skin: from physiological implications to clinical significances.
TRP channels in skin: from physiological implications to clinical significances.
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DOI：
10.2142/biophysics.11.17
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Lee CH
中科院分区：
文献类型：
--
作者：
Ho JC;Lee CH
TRP通道在皮肤中的各种细胞中表达。作为一个器官系统的边界主机和环境，许多非神经元细胞，包括表皮角质形成细胞和黑素细胞，表达几个TRP通道功能不同的感觉处理。表皮和毛器的角质形成细胞中的TRPV1和TRPV3抑制增殖，诱导终末分化，诱导凋亡，并促进炎症。TRPV4、6和TRPA1的激活促进了受损皮肤屏障的再生。TRPA1还增强接触性超敏反应。角质形成细胞中的TRPC调节表皮分化。在具有扰乱的表皮分化的人类疾病中，TRPC的表达改变。TRPMs有助于黑素细胞中黑素的产生，是转移性黑色素瘤患者的重要预后标志物。总之，TRP通道不仅在感觉加工中起作用，还有助于表皮分化、增殖、屏障整合、皮肤再生和免疫应答。在具有异常TRP通道的疾病中，TRP通道可能是良好的治疗靶点。
TRP channels are expressed in various cells in skin. As an organ system to border the host and environment, many nonneuronal cells, including epidermal keratinocytes and melanocytes, express several TRP channels functionally distinct from sensory processing. TRPV1 and TRPV3 in keratinocytes of the epidermis and hair apparatus inhibit proliferation, induce terminal differentiation, induce apoptosis, and promote inflammation. Activation of TRPV4, 6, and TRPA1 promotes regeneration of the severed skin barriers. TRPA1 also enhances responses in contact hypersensitivity. TRPCs in keratinocytes regulate epidermal differentiation. In human diseases with pertubered epidermal differentiation, the expression of TRPCs are altered. TRPMs, which contribute to melanin production in melanocytes, serve as significant prognosis markers in patients with metastatic melanoma. In summary, not only act in sensory processing, TRP channels also contribute to epidermal differentiation, proliferation, barrier integration, skin regeneration, and immune responses. In diseases with aberrant TRP channels, TRP channels might be good therapeutic targets.